Results 81 to 90 of about 5,601,650 (302)

Enabling urban futures making through early-stage and punctuated design prototyping: the case of T-Factor local innovation hubs

Frontiers in Sustainable Cities
Futures thinking is a crucial skill for organisations navigating volatile, uncertain, complex, and ambiguous environments. Nonetheless, some researchers and practitioners argue that the insights futures thinking can yield appear obvious, trivial, or ...
Maria Vitaller del Olmo, Luca Simeone, Beatrice D’Ippolito, Amalia de Götzen, Nicola Morelli   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The design of a model for providing information at local museums through mobile devices with Beacon technology

Journal of Graphic Engineering and Design
This research aimed 1) to study the information and information system of the museum, 2) to create a system for providing information within the museum via mobile applications, and 3) to assess the satisfaction of the users of information system within ...
Chayanis Chuenchaichon, Waraporn Mamee, Sakeson Yanpanyanon   +2 more
doaj   +1 more source

Correction to: Harnessing digital workflows for the understanding, promotion and participation in the conservation of heritage sites by meeting both ethical and technical challenges

Built Heritage, 2020
In the original publication of this article (Quintero et al., 2020) the family name of the last author is incorrect. The correct family name of the last author should be Barazzetti rather than Barazetti. The original publication has been corrected.
Mario Santana Quintero, Reem Awad, Luigi Barazzetti   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

User-Centered Pipeline for Synthetic Augmentation of Anomaly Detection Datasets

Computers
Automatic anomaly detection plays a critical role in surveillance systems but requires datasets comprising large amounts of annotated data to train and evaluate models. Gathering and annotating these data is a labor-intensive task that can become costly.
Alexander Rosbak-Mortensen, Marco Jansen, Morten Muhlig, Mikkel Bjørndahl Kristensen Tøt, Ivan Nikolov   +4 more
doaj   +1 more source

Harnessing digital workflows for the understanding, promotion and participation in the conservation of heritage sites by meeting both ethical and technical challenges

Built Heritage, 2020
The current application of digital workflows for the understanding, promotion and participation in the conservation of heritage sites involves several technical challenges and should be governed by serious ethical engagement.
Mario Santana Quintero, Reem Awad, Luigi Barazzetti   +2 more
doaj   +1 more source

Interactive and Media Architecture – From Social Encounters to City Planning Strategies☆

, 2016
The paper searches into the potential of media and interactive projects to support participation and generate social encounters in public spaces. Moreover, it proposes implementation of media and interactive projects into city planning processes.
Katarzyna Urbanowicz, Lucyna Nyka
semanticscholar   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Media and Architecture

Interactive Film & Media Journal
This paper proposes to study the influence of cinema and media on the built environment in contemporary India. Following the reorganisation of the states since the new millennium there has been a demand to build cities, either as ‘new’ capital cities for the bifurcated states or as globally inflected cities for trade, commerce, and employment.
openaire   +1 more source