Results 101 to 110 of about 18,136,290 (245)
Media bias and electoral discourse
La Revista Icono 14This study employs quantitative and artificial intelligence methods to scrutinize media coverage during an election campaign. Employing TF, TF*IDF, and word2vec for text quantification and vectorization, alongside UAMP and t-SNE for cluster analysis, we
Mar Castillo-Campos +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2014 This chapter deals with electronic discourse by discussing the pragmatics of language use in computer-mediated settings. In many so-called first world countries, accessing the Internet by means of a computer or a smartphone, etc.
Locher, Miriam A.
core
Neuropsychological correlates of discourse production in schizophrenic patients
, 2007 86 Italian-speaking participants (30 Schizophrenic patients and 56 normal controls) matched for chronological age and level of formal education were included in the study. All participants underwent accurate neuropsychological examination.
Caltagirone C. +3 more
core +1 more source
Dire le « migrant » dans la ville : une analyse de discours médiatique [PDF]
Studii de Lingvistica, 2018 This paper aims at revealing the processes at work in the formation of the political image of the “migrant” in the media. Analysing a corpus of national, regional and local press articles, the idea is to ask: who are we talking about?
Thomas Vetier
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source