Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Media education and educational commons for youth civic engagement. A case study from the Horizon 2020 project SMOOTH. [PDF]
Front Sociol, 2022 Cappello G, Siino M.
europepmc +1 more source
In this lesson students will discover how a submersible's design enables humans to explore the deep ocean. As a result of doing this activity, students will understand that the physical features of water can be restrictive to movement.
core
Investing in Youth Media: A Guide for Grantmakers [PDF]
, 2006 Investing in Youth Media is a compilation of success stories, lessons, and guidance for grantmakers interested in being part of the vibrant and growing field of youth media.
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A pedagogical model for simulation-based learning in healthcare
Seminar.net, 2015 The aim of this study was to design a pedagogical model for a simulation-based learning environment (SBLE) in healthcare. Currently, simulation and virtual reality are a major focus in healthcare education.
Tuulikki Keskitalo, Heli Ruokamo
doaj
Examination of influence of social media education through mobile phones on the change in physical activity and sedentary behavior in pregnant women: a randomized controlled trial. [PDF]
BMC Womens Health, 2022 Talebi E +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Students’ Expectations and Experiences of Meaningful Simulation-Based Medical Education
Seminar.net, 2016 This study aims to investigate students’ expectations and experiences of meaningful learning in simulation-based learning environments. We set the following research question: How do students’ experiences of meaningful simulation-based learning ...
Tuulikki Keskitalo, Heli Ruokamo
doaj
The Integration and Development of Piano Art and Media Education and Its Influence on the Long-Term Care and Happiness of the Elderly People. [PDF]
Front Psychol, 2021 Chen X, Huang F, Wang Y.
europepmc +1 more source