Results 61 to 70 of about 647,621 (267)

數位設計領域學生在大學社會責任計畫中的跨文化設計能力學習經驗 Undergraduates’ Learning Experience of Intercultural Design Competence in the Field of Digital Design through the Participation in the University Social Responsibility Program

Journal of Curriculum Studies
跨文化設計能力是指設計者具有文化適切性的設計能力，本研究以東部一所大 學的學生為對象，運用質性訪談輔以作品分析的方式，探究其透過參與大學社會責任計畫，以原住民族社區文化為主題的動畫影片製作過程中之跨文化設計能力學習經驗。研究發現，學生習得之跨文化設計能力包括：展現跨文化的尊重與探究態度，也能運用適切的探究、溝通及合作等設計所需技術，將習得之原住民族文化知識內容融入作品中。也因與在地社區文化的真實連結，跨文化的碰撞刺激了學生創意及思考，而創作出的作品亦可提供社區作為宣傳行銷之用。因此 ...
劉淳泓 Chun-Hung Liu , 張如慧 Ju-Hui Chang   +1 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Supporting Early Childhood Preservice Teachers to Effectively Integrate STEM in Their Future Teaching Practice

Education Sciences
It is critical that teachers are equipped with Science, Technology, Engineering and Mathematics (STEM) skills and knowledge as we move into a digital future.
Sarika Kewalramani, Anamika Devi, Andrea Ng   +2 more
doaj   +1 more source

Assessing Paragraph Knowledge among University Student Teachers: Insights from a Positivist Study [PDF]

Journal of Education and Learning Technology
This study investigated the knowledge of paragraph structure and texture among Upper Primary Specialism student-teachers in the Department of Basic Student Education, School of Education and Life-Long Learning, University of Education, Winneba.
Shine Lillian Gifty Agbevivi, Ernest Kwesi Klu, Emmanuel Sikitime, Vincent Demana   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Social Media Advanced Educational Technology in Media Education

Architecture Image Studies
What started as a dormitory online forum for college students has become a mega power in social media world. This is how social media, a fad among college students or a rage in social networking domain, can be described in a nutshell. Then later it become most powerful tool for education.
Suleiman Ibrahim Mohammad, Raja Natarajan, Asokan Vasudevan   +2 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source