Results 61 to 70 of about 910,538 (316)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Media Education in the Polish System of Mainstream Education

Media, Biznes, Kultura
The article discusses the role of media education in the Polish system of general education, focusing on primary media literacy aimed at developing critical and conscious media consumptions skills ...
Katarzyna Adamczyk
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Critical Media Literacy and Islamist Online Propaganda: The Feasibility, Applicability and Impact of Three Learning Arrangements

International Journal of Conflict and Violence, 2019
The networked structure of the internet facilitates the dissemination of extremist messages and often makes removal impossible. Equipping media users with critical (preventive) skills appears a more promising strategy than trying to block any exposure to
Josephine B. Schmitt, Diana Rieger, Julian Ernst, Hans-Joachim Roth   +3 more
doaj   +1 more source

Media Education Challenges in a Digital Society: The Case of Chile

, 2021
The executive council of UNESCO claims that media and information literacy (MIL) constitutes a concern for the entire world, due to the primary role of information, technology, and media in everyday life and in participating in every aspect of public ...
Condeza, Ana Rayén, Fernández Medina, Francisco Javier, Gálvez Johnson, Myrna, Herrada Hidalgo, Nadia   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Critical Media Literacy and Islamist Online Propaganda: The Feasibility, Applicability and Impact of Three Learning Arrangements

International Journal of Conflict and Violence, 2018
The networked structure of the internet facilitates the dissemination of extremist messages and often makes removal impossible. Equipping media users with critical (preventive) skills appears a more promising strategy than trying to block any exposure to
Josephine B. Schmitt, Diana Rieger, Julian Ernst, Hans-Joachim Roth   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Art of Compassionate Communication: LinkedIn’s Well-Being Practices as a Model of Humanistic Organisational Communication

Art of Humanistic Management Journal
The aim of this article is to identify and characterise the well-being practices implemented by LinkedIn, thereby presenting a model of humanistic and compassionate organisational communication.
Małgorzata Laskowska , Krzysztof Marcyński   +1 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source