Results 51 to 60 of about 66,044 (308)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

A sporting chance for women? Exploring gender imbalance on the sports desks of UK national newspapers [PDF]

open access: yes, 2016
Sports journalism has traditionally been seen as a male domain, and a number of researchers suggest that this tradition has not changed (Strong, 2007) . Sports reporters in the United Kingdom remain predominantly male, and despite increasingly more women
Franks, Suzanne, O'Neill, Deirdre
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Inside the Wardrobe: Fashioning a Fashionable Life

open access: yesEuropean Journal of Life Writing, 2019
This article looks to the manifestation of the personal wardrobe in digital fashion media. It focuses upon the example of British Vogue’s YouTube series ‘Inside the Wardrobe’ and episodes that feature, firstly Vogue Fashion Editor Sarah Harris and Vogue ...
Felice McDowell
doaj   +1 more source

Science and the media: securing the future [PDF]

open access: yes, 2010
A report by the Science and the Media Expert Group, in which actions and recommendations are made which are aimed at delivering changes to improve the quality of science in the media and also stimulate an important debate about the future of science ...

core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

KARTUN KARIKATUR MEDIA KOMUNIKASI SOSIAL DALAM MEDIA CETAK

open access: yesGelar: Jurnal Seni Budaya, 2016
Caricature Cartoon, a whole word that can be realized in the picture. Pictures like this are usually found in the print media, newspapers, magazines and books. Some of the readers sometimes only a cursory look, if by chance they are definitely worth high
Sri Indratmi Yudiarti
doaj   +1 more source

'Gender as a multi-layered issue in journalism: ' A multi-method approach to studying barriers for women in Belgian newsrooms [PDF]

open access: yes, 2014
In recent years, in feminist media studies there has been a growing interest in in media production processes, the structures of media organizations and the people working ‘behind the scenes’ of these companies.
De Vuyst, Sara, Raeymaeckers, Karin
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

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