Results 61 to 70 of about 3,082 (259)
Freelance working: Mobile technology and social media
, 2017 Freelance workers are important contributors to the United Kingdom’s (UK) economy and they are growing significantly not at least because technology enables them to work on their own account. Reports based on Labour Force Survey (LFS) data estimate that there were 1.9 million freelance workers in the UK in 2015, constituting 6% of all UK workers in ...
Reuschke, Darja, Wilkins, Annabelle H.
openaire +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The California Gig Economy Law
Voices in Bioethics, 2020 Photo by Morning Brew on Unsplash INTRODUCTION Employer-based insurance models work when the laws compelling employers to offer insurance are enforced. Corporate failure to provide insurance to full time employees undermines the system and results in
Anne Zimmerman
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
tripleC: Communication, Capitalism & Critique, 2014 This podcast is a recording of Jim McGuigan's talk "The Work of Raymond Williams" that he presented in the CAMRI Research Seminar at the University of Westminster on October 15, 2014.
Jim McGuigan
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Analysis of organizational and managerial structure on the case of Serbian film association [PDF]
Ekonomija: teorija i praksa, 2015 Serbian Film Commission (with the brand name - FilminSerbia) is the first film association in Serbia, which operates as an independent, nonprofit, professional association.
Simić Vladimir
doaj
Jornal Vascular Brasileiro, 2012 CONTEXTO: Atualmente há um crescente interesse por instrumentos de avaliação em saúde produzidos e validados em todo o mundo. Apesar disso, ainda não temos no Brasil instrumentos que avaliem o impacto da doença venosa crônica na vida de seu portador ...
Flávia de Jesus Leal +6 more
doaj +1 more source