Results 151 to 160 of about 50,853,159 (386)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Effects of Social Media: Is it Hurting College Students? [PDF]

, 2015
This study evaluates the relationship between how frequently college students’ access social media sites in class, and their GPA. Our class sent out an electronic survey and had 264 respondents, including men, women and transgender individuals.
Landry, Megan
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

What Makes the Headlines: A Five-Year Analysis of the Front Page of the 'Ghanaian Times'

Journal of Arts, Humanities and Social Science
This study aimed to identify the various story types featured on the front pages of the ‘Ghanaian Times’ newspaper. Utilising the gatekeeping and framing theories, the study aimed to establish the dominant story types, news actors, and story settings ...
Kwaku Baah-Acheamfour, Judith Lamptey-George   +1 more
doaj   +1 more source

The Role of Linguistics Studies on the Political Debate [PDF]

, 2019
The paper is to find out the linguistics role contribution towards the political debate event at the election party. The presidential debate\u27s primary purpose is to sponsor and produce debates for the United States presidential and vice-presidential ...
Collins, L. (Lee), Jisum, C. (Chang)
core  

Synthesis and study of photosensitive chromone derivatives for recording media of archival three-dimensional optical memory

, 2008
Mikhail M. Krayushkin, K. S. Levchenko, V. N. Yarovenko, И. В. Заварзин, V. А. Barachevsky, Yury A. Puankov, Т. М. Валова, О. И. Кобелева   +7 more
openalex   +2 more sources

Health Care Professional's Knowledge of Pregnancy Complications and Women's Cardiovascular Health: An International Study Utilizing Social Media

, 2022
Pensée Wu, Mamas A. Mamas, Martha Gulati   +2 more
openalex   +2 more sources

Media studies to enhance the production of verticillins facilitated by in situ chemical analysis. [PDF]

J Ind Microbiol Biotechnol, 2018
Amrine CSM, Raja HA, Darveaux BA, Pearce CJ, Oberlies NH.   +4 more
europepmc   +1 more source

The genome incorporated: constructing biodigital identity [PDF]

, 2010
The Genome Incorporated examines the proliferation of human genomics across contemporary media cultures. It explores questions about what it means for a technoscience to thoroughly saturate everyday life, and places the interrogation of the science/media
O'Riordan, Kate
core   +1 more source