Results 101 to 110 of about 24,307 (213)

Orchestrated molecular changes of proliferative, migratory‐fibrillar, synaptic, and postmigratory compartments align with precocious cortex‐type specification in the early human pallium

Journal of Anatomy, EarlyView.
Early human cortical development is organized by transient cellular compartments that define cortical types before mature layers form. Analysis of the human fetal pallium (7.5–15 PCW) shows distinct spatiotemporal trajectories for the archicortex, mesocortex, and neocortex, with delayed but accelerated differentiation in allocortical regions.
Janja Kopić, Fran Božić, Alisa Junaković Munjas, Željka Krsnik, Ivica Kostović   +4 more
wiley   +1 more source

Anatomical and Electrophysiological Clustering of Superficial Medial Entorhinal Cortex Interneurons [PDF]

eneuro, 2017
AbstractLocal GABAergic interneurons regulate the activity of spatially-modulated principal cells in the medial entorhinal cortex (MEC), mediating stellate-to-stellate connectivity and possibly enabling grid formation via recurrent inhibitory circuitry. Despite the important role interneurons seem to play in the MEC cortical circuit, the combination of
Joan José Martínez, Bahar Rahsepar, John A. White   +2 more
openaire   +2 more sources

Do fawn‐footed mosaic‐tailed rats experience age‐related cognitive decline in novel object recognition?

Journal of Zoology, EarlyView.
We explored age‐related cognitive decline in captive fawn‐footed mosaic‐tailed rats (Melomys cervinipes) using a novel object recognition task. Contrary to expectations, recognition memory did not decline with age, but recognition memory was lower in intermediate‐aged rats compared to both older and younger individuals.
K. DiBenedetto, M. K. Rowell, T. L. Rymer   +2 more
wiley   +1 more source

Stereotyped network dynamics in the medial entorhinal cortex

, 2020
Poster for FENS2020.The medial entorhinal cortex (MEC) supports the brain’s representation of space with distinct cell types (grid, border, object-vector, head-directions and speed cells). Since no single sensory stimulus can faithfully predict the firing of these cells, attractor network models postulate that spatially-tuned firing emerges from ...
Cogno, Soledad Gonzalo, Donato, Flavio, Obenhaus, Horst A., R. Irene Jacobsen, May-Britt Moser, Moser, Edvard I.   +5 more
openaire   +1 more source

Carbachol induces fast oscillations in the medial but not in the lateral entorhinal cortex of the isolated guinea pig brain [PDF]

, 1999
Fast oscillations at 25–80 Hz (gamma activity) have been proposed to play a role in attention-related mechanisms and synaptic plasticity in cortical structures.
van der Linden, S., Solange van der Linden, Marco de Curtis, Ferruccio Panzica, Panzica, F., De Curtis, M.   +5 more
core   +1 more source

Functional topography of the human entorhinal cortex

eLife, 2015
Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive.
Tobias Navarro Schröder, Koen V Haak, Nestor I Zaragoza Jimenez, Christian F Beckmann, Christian F Doeller   +4 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Challenges for identifying the neural mechanisms that support spatial navigation: the impact of spatial scale [PDF]

, 2014
Spatial navigation is a fascinating behavior that is essential for our everyday lives. It involves nearly all sensory systems, it requires numerous parallel computations, and it engages multiple memory systems.
Wolbers, Thomas, Thomas eWolbers, Wiener, J.M., Thomas Wolbers, Thomas Wolbers, Jan M. Wiener   +5 more
core   +1 more source

Integration of cortical inputs in the lateral hypothalamus is dominated by the medial prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend The lateral hypothalamus (LH) is a critical controller of innate behaviours such as feeding. It is anatomically connected to specific cortical areas. We mapped these areas using a combination of retrograde tracing and anterograde optogenetic circuit mapping.
Lotte J. A. M. Razenberg, Pieter Nicolaas de Greef, Huibert D. Mansvelder, Mahesh Miikael Karnani   +3 more
wiley   +1 more source

Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro [PDF]

, 1996
1. Injection of aminooxyacetic acid (AOAA) into the entorhinal cortex in vivo produces acute seizures and cell loss in medial entorhinal cortex. To understand these effects, AOAA was applied directly to the medial entorhinal cortex in slices containing ...
H. E. Scharfman
core   +1 more source