Results 101 to 110 of about 22,462 (202)

Heterosynaptic NMDA receptor plasticity in hippocampal dentate granule cells

Frontiers in Synaptic Neuroscience
The dentate gyrus is a key relay station that controls information transfer from the entorhinal cortex to the hippocampus proper. This process relies heavily on dendritic integration by dentate granule cells (GCs) of excitatory synaptic inputs from the ...
Kaoutsar Nasrallah, Kaoutsar Nasrallah, Maryann Castillo, Stefano Lutzu, Pablo E. Castillo, Pablo E. Castillo, Alma Rodenas-Ruano, Alma Rodenas-Ruano   +7 more
doaj   +1 more source

Exploring longitudinal relationships among Alzheimer's disease biomarkers

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION While most studies of Alzheimer's disease (AD) examine cross‐sectional relationships among biomarkers, longitudinal relationships are also highly relevant. METHODS This study in the Alzheimer's Disease Neuroimaging Initiative cohort (n = 373) used non‐parametric Spearman correlations to explore the relationships of baseline values
Benjamin Saef, Kellen K. Petersen, Katherine Volluz, Yan Li, Duygu Tosun, Marta Mila‐Aloma, Leslie M. Shaw, Henrik Zetterberg, Jeffrey L. Dage, Carrie E. Rubel, Kyle Ferber, Lei Du‐Cuny, Janaky Coomaraswamy, Michael Baratta, Yulia Mordashova, Ziad S. Saad, Gallen Triana‐Baltzer, Nicholas J. Ashton, Emily A. Meyers, Erin G. Rosenbaugh, J. Martin Sabandal, Anthony W. Bannon, William Z. Potter, Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team, Suzanne E. Schindler   +25 more
wiley   +1 more source

Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

Nature Communications, 2019
Medial entorhinal cortex (MEC) is involved in memory processes that entail the replay of sequential firing of hippocampal place cells during rest periods and during behaviour.
Alireza Chenani, Marta Sabariego, Magdalene I. Schlesiger, Jill K. Leutgeb, Stefan Leutgeb, Christian Leibold   +5 more
doaj   +1 more source

Sex specificity of resistance to caTAUstrophe

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION As amyloid beta (Aβ) accumulates, tau pathology spreads beyond medial temporal lobe (MTL) into neocortical (NEO) regions, though some older adults resist this progression, or what we call here “caTAUstrophe.” Given previous evidence of higher tau levels in women, we tested how tau resistance presented in men and women separately ...
Maria Carrigan, Colin Birkenbihl, Hannah M. Klinger, Oliver Langford, Gillian T. Coughlan, Mabel Seto, Jane A. Brown, Annie Li, Madison Cuppels, Michael Properzi, Jasmeer Chhatwal, Julie Price, Aaron Schultz, Dorene Rentz, Rebecca Amariglio, Harm J. Krugers, Rik Ossenkoppele, Keith Johnson, Reisa Sperling, Timothy J. Hohman, Michael Donohue, Rachel F. Buckley   +21 more
wiley   +1 more source

Brain morphometry patterns in the presence of Alzheimer's disease and/or LATE neuropathologic changes

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Alzheimer's disease neuropathologic change (ADNC) and limbic‐predominant age‐related transactive response DNA‐binding protein 43 kDa (TDP‐43) encephalopathy neuropathologic change (LATENC) are common in older adults, yet differences in brain morphometry patterns when one or both pathologies are present remain unclear.
Khalid Saifullah, Abdur Raquib Ridwan, Arnold M. Evia, Sue E. Leurgans, Maude Wagner, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +7 more
wiley   +1 more source

Rapid formation of non-spatial hippocampal representations consistent with behavioral timescale synaptic plasticity is modulated by entorhinal input

Nature Communications
Behavioral timescale synaptic plasticity (BTSP) is a form of synaptic potentiation where a single plateau potential in hippocampal neurons forms a place field during spatial learning.
Conor C. Dorian, Jiannis Taxidis, Ahmet Arac, Peyman Golshani   +3 more
doaj   +1 more source

Hormone replacement therapy and its association with LATE‐NC in older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA‐binding protein 43 (TDP‐43) encephalopathy neuropathological change (LATE‐NC) is a cause of dementia resembling Alzheimer's disease (AD). The 90+ Study found women using hormone replacement therapy (HRT) two to three decades before death had lower odds of LATE‐NC.
Yohana M. Kim, Katherine Colcord, S. Ahmad Sajjadi, Elizabeth J. Andrews, Julie A. Schneider, Claudia H. Kawas, Maria M. Corrada   +6 more
wiley   +1 more source

Sleep apnea in REM sleep as an amplifier of vascular contributions to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Obstructive sleep apnea (OSA), a common though underdiagnosed disorder in older adults, represents a potential upstream vascular stressor linked to increased Alzheimer's disease (AD) risk. In this Perspective article, we propose a stage‐informed framework in which rapid eye movement (REM) sleep‐related respiratory events amplify vascular ...
Destiny E. Berisha, Ruth M. Benca, Bryce A. Mander   +2 more
wiley   +1 more source

Arachnoid granulation morphologies and β‐amyloid and tau pathology in older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Arachnoid granulations (AG) prominently enlarge with age, yet limited studies evaluate AG in neurodegeneration. Here, we investigate the associations of AG morphologies with Alzheimer's disease (AD). METHODS Macroscopic AG properties were evaluated along dorsal post mortem brain specimens (n = 882).
Rashi I. Mehta, Tianhao Wang, Aubrey Lewis, Claire E. Walker, Caroline Gebczak, Lisa L. Barnes, David A. Bennett, Rupal I. Mehta   +7 more
wiley   +1 more source

Vulnerability of locus coeruleus connections to aging and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION The locus coeruleus (LC) is important in coordinating communication between brain regions through its widespread connections. However, the organization of its connections, and its changes with aging and Alzheimer's disease (AD), remains unclear.
Blanca Zufiria‐Gerbolés, Daniel Vereb, Mite Mijalkov, Massimiliano Passaretti, Giovanni Volpe, Zhilei Xu, Thomas Hinault, Sara Garcia‐Ptacek, Joana B. Pereira, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source