Results 111 to 120 of about 22,462 (202)

Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning

Translational Psychiatry
The entorhinal cortex and hippocampus are interconnected brain regions required for episodic learning and memory. For this functional encoding, correct assembly of specific synaptic connections across this circuit is critical during development. To guide
Jordan D. Donohue, Crisylle Blanton, Anna Chen, Amna Ahmad, Elizabeth D. Liu, Lisette Saab, Rajbir Kaur, Woojin Yang, Garret R. Anderson   +8 more
doaj   +1 more source

Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Subjective cognitive concerns frequently diverge from objective cognitive performance in cognitively unimpaired (CU) older adults, yet the neurobiological basis of this mismatch remains unclear. METHODS In 648 participants from the Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE), we defined four
Lu Wan, Chaeryon Kang, Rae Harrison, Patricio Solis‐Urra, Kelsey R. Sewell, Lauren E. Oberlin, Shivangi Jain, Haiqing Huang, George Grove, M. Ilyas Kamboh, Bradley P. Sutton, Beth E. Snitz, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles H. Hillman, Eric D. Vidoni, Anna L. Marsland, Thomas K. Karikari, Jill Morris, Kirk I. Erickson   +20 more
wiley   +1 more source

Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers

Annals of Neurology, Volume 100, Issue 2, Page 370-379, August 2026.
Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang, Sid E. O'Bryant, Robert A. Rissman, Leigh A. Johnson, Meredith N. Braskie, Kristine Yaffe, the HABS‐HD Study Team, Sid E. O'Bryant, Kristine Yaffe, Arthur Toga, Robert Rissman, Leigh Johnson, Meredith Braskie, Kevin King, James R. Hall, Melissa Petersen, Raymond Palmer, Robert Barber, Yonggang Shi, Fan Zhang, Rajesh Nandy, Roderick McColl, David Mason, Bradley Christian, Nicole Phillips, Stephanie Large, Joe Lee, Badri Vardarajan, Monica Rivera Mindt, Amrita Cheema, Lisa Barnes, Mark Mapstone, Annie Cohen, Amy Kind, Ozioma Okonkwo, Raul Vintimilla, Zhengyang Zhou, Michael Donohue, Rema Raman, Matthew Borzage, Michelle Mielke, Beau Ances, Ganesh Babulal, Jorge Llibre‐Guerra, Carl Hill, Rocky Vig   +45 more
wiley   +1 more source

HIF‐1α and HIF‐2α Are Upregulated in the Hippocampus but Not in the Medial Prefrontal Cortex in Experimental PTSD

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Post‐traumatic stress disorder (PTSD) is a psychiatric disorder characterized by anxiety, abnormal stress responses, and pathological memory formation. Research indicates that hypoxia‐inducible pathways might influence the neurobiology of PTSD.
Denys Porkhalo, Denis Pashevin, Yana Naumenko, Victor Dosenko   +3 more
wiley   +1 more source

Regional Functional Molecular Profiles Within the Mammalian Cortex: A Commentary on Limbic Mesocortex

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Two lateral mouse brain sagittal sections labeled, respectively, for Lypd1 (A) and Kcnab3 (B). (A) Lypd1 labels positively cortical Layers 2 and 5 (less heavily), but only at limbic mesocortical sites, forming the limbic ring that separates the unlabeled isocortex (IsoCx) from the unlabeled hippocampal and olfactory allocortex (Hi, Sub, ERh; OlfCx ...
Luis Puelles, Elena Garcia‐Calero
wiley   +1 more source

The perforant pathway and CA3-Schaffer collateral afferents coordinate to regulate spatial learning

Communications Biology
The entorhinal-hippocampal system constitutes a pivotal neural circuit in the central nervous system. It is critically involved in processing spatial learning and memory.
Fengwen Huang, Stephen Temitayo Bello, Siu Hin Lau, Jufang He   +3 more
doaj   +1 more source

Brain‐Wide Mapping and Synaptic Localization of C1QL3 Using a Novel Epitope‐Tagged Knock‐In Mouse

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
C1QL3 is a secreted adhesion molecule that acts as a key regulator of synaptic structure and function. We generated and validated a novel epitope‐tagged knock‐in mouse line (C1ql32HA) in which two hemagglutinin (HA) epitopes were inserted near the N‐terminus of the endogenous C1QL3 protein.
William P. Armstrong IV, James M. Salvatore, Matthew J. Sticco, Keaven Caro, J. Wesley Maddox, Angie Huang, Brenna C. McAllister, Christopher B. O'Connell, Siu‐Pok Yee, Amy Lee, Susanne Ressl, David C. Martinelli, Alexander C. Jackson   +12 more
wiley   +1 more source

Hippocampal sharp-wave ripples and their spike assembly content are regulated by the medial entorhinal cortex. [PDF]

Curr Biol, 2023
Zutshi I, Buzsáki G.
europepmc   +1 more source

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source

Population codes in medial entorhinal cortex

, 2014
Populasjonskoder i mediale entorhinal korteks Hjernebarken utfører kontinuerlig et velde av kompliserte funksjoner, hvis mekanismer vi kan tjene mye på å forstå. Nevrovitenskap er et relativt nytt fag, men med utrolig moment. Mye vites i dag om enkle nevroners egenskaper, men nevral komputering foregår i store trekk i interaksjonene mellom celler.
openaire   +1 more source