Results 151 to 160 of about 1,504 (212)

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Raising resilience: A parenting intervention for families affected by childhood epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite behavioral concerns reported among children with epilepsy, evidence‐based family‐focused interventions designed for this population remain limited. The objectives of this study were to characterize behavioral concerns and parent mental health needs in families of children with epilepsy relative to children with non‐epileptic ...
Samantha J. Feldman, Bianca C. Bondi, Chantal C. Cheung, Heather Olivieri, Tricia S. Williams   +4 more
wiley   +1 more source

Stereo‐electroencephalography–guided responsive neuromodulation: A propensity‐matched cohort study

Epilepsia, EarlyView.
Abstract Objective The optimal pre‐implantation evaluation and surgical targeting strategies for responsive neurostimulation (RNS) in patients with unresectable, drug‐resistant focal epilepsy continue to be debated. Although stereo‐electroencephalography (sEEG) is central to characterizing the seizure‐onset zone, its role in preoperative testing for ...
David Botros, Julian Brown, John D. Rolston, Paul A. House, Amir Arain, Matthew Jensen, Blake Newman, Brian Johnson, Sindhu Richards, Angela Peters, Shervin Rahimpour, Ben Shofty   +11 more
wiley   +1 more source

Epileptogenic lesions in the Australian epilepsy project: A harmonized 3‐T magnetic resonance imaging protocol and its diagnostic yield

Epilepsia, EarlyView.
Abstract Objective Detection of epilepsy‐causing structural brain lesions on magnetic resonance imaging (MRI) is critical for diagnosis, prognosis, and treatment planning in people with epilepsy. We aimed to establish an epilepsy‐directed multisite harmonized 3‐T MRI acquisition protocol for the Australian Epilepsy Project (AEP) and describe the ...
David N. Vaughan, David F. Abbott, Amanda Anderson, Greg Fitt, Suyi Ooi, Heath Pardoe, Donna Parker, Yuliya Perchyonok, Eric Pierre, Chris Kokkinos, Robert E. Smith, Michael Stewart, Bahman Tahayori, Chris Tailby, Graeme D. Jackson, the Australian Epilepsy Project Investigators, Zanfina Ademi, Patrick Kwan, Karen Oliver, Mangor Pedersen   +19 more
wiley   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Ventral anterior thalamic dysfunction distinguishes seizure generalization in temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Focal‐to‐bilateral tonic–clonic seizures (FBTCS) in temporal lobe epilepsy (TLE) involve thalamocortical networks, yet the functional integrity and role of specific thalamic subregions in seizure generalization remain unclear. In this cross‐sectional study, we investigated whether thalamic subregion functional connectivity patterns ...
Stacy N. Hudgins, Michael R. Sperling, Hasan Ayaz, Joseph I. Tracy   +3 more
wiley   +1 more source

Postoperative reduction of anti‐seizure medication is associated with cognitive improvement in seizure‐free patients after anterior temporal lobectomy

Epilepsia, EarlyView.
Abstract Objective To determine whether postoperative reduction of anti‐seizure medication (ASM) burden is associated with cognitive improvement after anterior temporal lobectomy (ATL) in seizure‐free patients. Methods We retrospectively analyzed data for adult patients with drug‐resistant temporal lobe epilepsy who underwent unilateral ATL between ...
Kazushi Ukishiro, Shin‐ichiro Osawa, Maimi Ogawa, Makoto Ishida, Takafumi Kubota, Kazutoshi Konomatsu, Hidenori Endo, Kazutaka Jin   +7 more
wiley   +1 more source

Temporal lobe epilepsy with bilateral amygdala enlargement mimicking behavioral variant frontotemporal dementia

Epileptic Disorders, EarlyView.
Kentaro Tokumoto, Takuji Nishida, Takashi Matsudaira, Etsuko Yamazaki, Norihiko Kawaguchi, Naotaka Usui, Katsumi Imai, Yushi Inoue   +7 more
wiley   +1 more source

Characterizing chapeau de gendarme in pediatric epilepsy through systematic video‐EEG evaluation

Epilepsia, EarlyView.
Abstract Objective Chapeau de gendarme (CdG) is a subtle but clinically relevant semiology that has been scarcely studied in children. Previous studies have primarily focused on its localizing value in small, surgical cohorts. This study aimed to systematically characterize frequency and clinical features of CdG across the pediatric age spectrum ...
Hanna Barbara Brinkmann, Lea Nakamura, Jan Schönberger, Julia Jacobs, Victoria San Antonio‐Arce, Kerstin Alexandra Klotz   +5 more
wiley   +1 more source

Does age influence diagnostic outcomes in an adult cohort referred to a first‐seizure clinic?

Epilepsia, EarlyView.
Abstract Objective The aging Danish population is associated with increasing morbidity and healthcare utilization. This study examines age‐related differences in resource utilization and diagnostic outcomes between older (65–95 years) and younger adults (18–64 years) evaluated for suspected epilepsy, including clinical management, diagnostic yield, and
Anne Line Lund Birkmose, Corinna Lackmann, Lars Hageman Pinborg, Kimmo Jensen   +3 more
wiley   +1 more source