Results 131 to 140 of about 5,576,912 (264)
The Median Voter and the Median Consumer: Local Private Goods and Residential Sorting [PDF]
When a product's product provision entails fixed costs, it will be made available only if a sufficient number of people want it. Some products are produced and consumed locally, so that provision requires not only a large group favoring the product but a
Joel Waldfogel
core
About one year ago (March 23, 2023) life as I knew it was upended by a terminal brain cancer diagnosis. What started as trouble with balance and walking escalated into a visit to my local hospital’s emergency room.
openaire +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The Median Probability Model and Correlated Variables
, 2018 The median probability model (MPM) Barbieri and Berger (2004) is defined as the model consisting of those variables whose marginal posterior probability of inclusion is at least 0.5.
Barbieri, Marilena +3 more
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
A United Probabilistic Approach to Minimising the Sum of Absolute Values
EkonometriaAim: Introduce a novel method for minimizing functions in the form of a sum of absolute values. Methodology: The sum of absolute values can be standardized so that the sum of the coefficients equals 1.
Changyong Feng +3 more
doaj
Median Labiomandibular Glossotomy
Annals of Surgery, 1971 H R, Tollefsen, R H, Spiro
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Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source