Results 111 to 120 of about 1,318,585 (312)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Strain-gradient mediated local conduction in strained bismuth ferrite films [PDF]

, 2019
It has been recently shown that the strain gradient is able to separate the light-excited electron-hole pairs in semiconductors, but how it affects the photoelectric properties of the photo-active materials remains an open question.
Alexe, Marin, Iqbal, Affan, Peters, Jonathan J. P., Sánchez, Ana M., Yang, Ming-Min   +4 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Associations of weight-adjusted-waist index and systemic immune-inflammatory index with sKlotho: evidence from the NHANES 2007-2016

Frontiers in Endocrinology
BackgroundKlotho is an anti-aging protein, and obesity and inflammation have been identified as having a relationship with Klotho. This study investigated the correlation between weight-adjusted-waist index(WWI), systemic inflammation index(SII) and ...
Mingming Yang, Qiong Xu, Linjuan Huang, Luqian Zhu   +3 more
doaj   +1 more source

Perfectionism and exam performance: The mediating effect of task-approach goals [PDF]

, 2015
Perfectionistic strivings are positively correlated with students’ achievement goals and exam performance. However, so far no study has employed a prospective design investigating whether achievement goals mediate the positive relationship between ...
Amy E. Haskew, Baron, Campbell, Charlotte Scott, Damian, Elliot, Elliot, Enns, Flett, Flett, Frost, Hewitt, Hewitt, Hill, Joachim Stoeber, Kutner, Maltby, Moller, Noftle, Preacher, Siu-Man, Slaney, Stoeber, Stoeber, Stoeber, Stoeber, Stoeber, Tabachnick, Yang   +28 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Testing high-dimensional mediation effect with arbitrary exposure–mediator coefficients

TEST
In response to the unique challenge created by high-dimensional mediators in mediation analysis, this paper presents a novel procedure for testing the nullity of the mediation effect in the presence of high-dimensional mediators. The procedure incorporates two distinct features.
Yinan Lin, Zijian Guo, Baoluo Sun, Zhenhua Lin   +3 more
openaire   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Joint association of sleep duration and depression with new-onset hearing loss: a national cohort study

Frontiers in Nutrition
BackgroundHearing loss, a global health burden, is closely associated with depression and sleep disorders. However, the combined effects of sleep duration and depression on hearing loss risk remain unclear.MethodsData from the China Health and Retirement
Fang Wang, Yu-Jun Xiong, Da-Ming Shao, Tian Lv, Shiqin Chen, Qian-Yuan Zhu   +5 more
doaj   +1 more source

PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL TERHADAP TURNOVER INTENTION DENGAN IKLIM ORGANISASI SEBAGAIVARIABEL MEDIASI ( Studi Kasus : Karyawan PT. Sejahtera Buana Trada di Kota Malang ) [PDF]

This research aims to determine and analyze the influence of transformational leadership style on turnover intention through organizational climate as a mediating variable.
Azmi, Amirul Mukminin Rafli
core