Results 91 to 100 of about 792,576 (296)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Understanding biodiversity effects on trophic interactions with a robust approach to path analysis

Cell Reports Sustainability
Summary: With its facility to assess causal mechanisms among multiple variables, the application of path analysis in medical, natural, and social sciences has become widespread.
Yu-Quan Wang, Da-Peng Shi, Christoph Scherber, Ben A. Woodcock, Yue-Qing Hu, Nian-Feng Wan   +5 more
doaj   +1 more source

THE LINK BETWEEN HUMAN DEVELOPMENT AND TAX COMPLIANCE: EVIDENCE FROM A MEDIATION ANALYSIS [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015
By performing mediation analysis with the state-of-the-art bootstrapping technique (95% bias-corrected and accelerated confidence interval; 5000 bootstrap resamples) on a worldwide sample pool of countries and territories, it is shown that human ...
BǍTRÂNCEA LARISSA
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Urinary N-acetylglucosaminidase in People Environmentally Exposed to Cadmium Is Minimally Related to Cadmium-Induced Nephron Destruction

Toxics
Exposure to even low levels of the environmental pollutant cadmium (Cd) increases the risk of kidney damage and malfunction. The body burden of Cd at which these outcomes occur is not, however, reliably defined.
Soisungwan Satarug
doaj   +1 more source

Does Nationality Influence Neutrality? The Ethical Standards and Expectations of International Mediators [PDF]

, 2016
This Comment examines how a mediator’s nationality can influence the mediating parties’ and communities’ perceptions of his neutrality and how cultural differences play a role in the ethical expectations of a cross-cultural mediator. Part I discusses the
Katsoris, Melissa
core   +1 more source

Higgs Mediation with Strong Hidden Sector Dynamics

, 2014
We present a simple model that achieves $m_h\approx 126$ GeV in the MSSM with large $A$-terms and TeV-scale stops through a combination of gauge mediation and Higgs-messenger interactions.
Knapen, Simon, Shih, David
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

EDITORIAL – MEDIATION ANALYSIS: ISSUES AND RECOMMENDATIONS [PDF]

Journal of Applied Structural Equation Modeling, 2018
Mumtaz Ali Memon, Jun-Hwa Cheah, T. Ramayah, Hiram Ting, Francis Chuah   +4 more
doaj   +1 more source

Lipids, Apolipoproteins, Lipid‐Lowering Drugs, and the Risk of Cerebral Small Vessel Disease: A Mendelian Randomization Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Serum lipids are causally involved in the occurrence of atherosclerosis, but their roles in cerebral small vessel disease remain unclear. This study aimed to investigate the causal roles of lipid or apolipoprotein traits in cerebral small ...
Yi Xie, Shuai Liu, Xinyue Wang, Hao Huang, Minghuan Wang, Wensheng Qu, Zhiyuan Yu, Wei Wang, Xiang Luo   +8 more
doaj   +1 more source