Results 121 to 130 of about 792,576 (296)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effects of different types of milk consumption on Crohn's disease and the mediating effects of amino acids: A Mendelian randomization study

Journal of Dairy Science
: Dietary therapy is a common adjunctive treatment for Crohn's disease (CD). However, previous studies have presented conflicting views on whether dairy products should be included in dietary therapy.
Wen-Jiang Zhao, Qing-Ao Xiao
doaj   +1 more source

Mediation Analysis with Multiple Exposures and Multiple Mediators

Statistics in Medicine
ABSTRACTA mediation analysis approach is proposed for multiple exposures, multiple mediators, and a continuous scalar outcome under the linear structural equation modeling framework. It assumes that there exist orthogonal components that demonstrate parallel mediation mechanisms on the outcome, and thus is named principal component mediation analysis ...
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A network and mediation analysis on the associations between family environment and suicidal ideation in adolescents in a psychiatric clinical setting

Frontiers in Psychiatry
BackgroundFamily environmental factors are known to contribute to adolescent suicidal ideation (SI), but how these factors interact and relate to SI needs further investigation.AimsTo examine how family factors interact with each other and are associated
Xing-Yan Liu, Shu-Hui Xu, Wen-Jing Yan, Li-Li Zhu, Cheng-Han Li   +4 more
doaj   +1 more source

Do psychobiosocial states mediate the relationship between perceived motivational climate and individual motivation in youngsters? [PDF]

Grounded in achievement goal theory and self-determination theory, this cross-sectional study examined the relationship between perceived motivational climate and individuals’ motivation as well as the mediation effect of psychobiosocial states as ...
Bertollo, Maurizio, Bortoli, Laura, Filho, Edson, Robazza, Claudio   +3 more
core  

Subgroup Mediation Analysis

Stat
ABSTRACTImaging genetics–based mediation analysis provides a powerful approach to understanding gene–brain–cognition pathways. However, despite recent progress, several challenges involving group‐level and subject‐level heterogeneity remain largely unaddressed.
Kaizhou Lei, Shengxian Ding, Lexin Li, Chao Huang   +3 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mala flavor preference increases risk of excessive gestational weight gain mediated by high-carbohydrate dietary patterns in Chongqing, China: an ambispective cohort study

Frontiers in Nutrition
Taste preference drives food selection, acceptance, or rejection and influences nutritional status and body mass index. Nevertheless, there are few reports concerning pregnant women.
Jinghua Li, Difei Wang, Yanyan Mao, Wuxia Zhang, Qianxi Zhu, Jun Liu, Jing Du, Weijin Zhou, Weijin Zhou, Fen Wang, Min Li   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source