Results 131 to 140 of about 792,576 (296)

The mediating effect of self-perceived aging on social capital and depression among Chinese community-dwelling older adult: a cross-sectional study

Frontiers in Public Health
BackgroundAmid an aging society, boosting older adult social capital is crucial to meet their growing health needs. This could be an effective way to alleviate the shortage of public health resources and improve the mental health of the older adult ...
Yuguo Ye, Hui Liu, Ziming Wang, Qianwei Zhang, Shifan Yang, Lian Yang   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Dietary inflammation and socioeconomic status mediate depression–constipation link: a cross-sectional analysis of NHANES 2005–2010

Frontiers in Nutrition
BackgroundThis study investigated the relationship between depression and constipation and examined potential mediating roles of dietary inflammatory index (DII) and socioeconomic status using data from NHANES 2005–2010.MethodsWe analyzed 12,854 adults ...
Qiulu Huang, Haifang Zhou, Mei Yang, Yilin Meng, Lina Wang   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Mediated discourse analysis [PDF]

, 2020
openaire   +2 more sources

The association between dietary fiber intake and cognitive function: mediating role of inflammatory markers

Frontiers in Nutrition
AimsCognitive impairment, frequently associated with neurodegenerative diseases such as Alzheimer's disease, may be associated with multiple factors including dietary fiber intake and inflammation.
Kaiyun Yan, Xinshuo Wang, Fengdan Wang, Baiyang Chen, Ziyu Zong, Jing Tian, Jing Zhao, Bo Li   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The impact of physical activity and dietary habits on glycolipemic metabolism and inflammatory markers in the elderly: a cross-sectional study

Frontiers in Nutrition
ObjectiveMetabolic syndrome and chronic inflammation significantly impact the quality of life of the elderly. Physical activity and dietary habits are two of the most important modifiable aspects of lifestyle. Thus, this study investigated the effects of
Wentao Zhang, Limin Zou, Jiangang Chen
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Mediating Role of Family Communication in the Relationship Between Academic Achievement Pressure and Problematic Smartphone Use Among Korean Early Adolescents

Children
Background/Objectives: Problematic smartphone use among early adolescents is a growing public health concern, often influenced by psychosocial stressors such as parental academic achievement pressure.
Hwa-Mi Yang
doaj   +1 more source