Results 101 to 110 of about 227,127 (342)

Drawing a Line Between Killing and Letting Die: The Law, and Law Reform, on Medically Assisted Dying [PDF]

, 1993
Traditional medical ethics and law draw a sharp distinction between allowing a patient to die and helping her die. Withholding or withdrawing life sustaining treatment, such as by abating technological nutrition, hydration or respiration, will cause ...
Gostin, Lawrence O.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Le jugement éthique dans l’évaluation des demandes d’aide médicale à mourir au Canada et au Québec : que nous apprennent les autres juridictions ?

Sociologies, 2023
This paper concerns the ethical judgment that lies at the heart of assessing requests for Medical Assistance in Dying (MAID) in Canada and Quebec, namely is it ethically right to help the person requesting assistance to end his or her life?
Mona Gupta, Samuel Blouin
doaj  

Euthanizing people who are 'tired of life' [PDF]

, 2017
In Belgium and the Netherlands, a debate is developing about people who express a desire to end their lives although they do not suffer from an incurable, life-threatening disease.
Cohen-Almagor, Raphael
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Medical Assistance in Dying—Unanswered Questions [PDF]

JAMA Internal Medicine, 2018
Joseph L, Verheijde, Mohamed Y, Rady
openaire   +4 more sources

Assisted death in eating disorders: a systematic review of cases and clinical rationales

Frontiers in Psychiatry
BackgroundAssisted dying for reasons solely related to an eating disorder (ED) has occurred in multiple countries, including those which restrict the practice to individuals with a terminal condition.
Chelsea Roff, Catherine Cook-Cottone
doaj   +1 more source

Irremediable psychiatric suffering in the context of medical assistance in dying: a qualitative study [PDF]

, 2021
Sisco van Veen, A.M. Ruissen, Aartjan T.F. Beekman, Natalie Evans, Guy Widdershoven   +4 more
openalex   +1 more source

Addressing Student Nurses\u27 Concerns in End of Life Care [PDF]

, 2006
Recently, there has been a great deal of attention to the fact that there are few learning opportunities regarding end-of-life (EOL) care in nursing undergraduate education.
Boroughf, Tami
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source