Results 31 to 40 of about 597,603 (289)

Identification of Small Molecules that Modulate Mutant p53 Condensation

iScience, 2020
Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions ...
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann   +21 more
doaj   +1 more source

Seventy years of biochemical subjects' development in pharmacy curricula: Experience from Serbia [PDF]

Journal of Medical Biochemistry, 2016
Introduction: The pharmacists played an important role in the development of biochemistry as applied chemistry in Serbia. What is more, the first seven state chemists in Serbia were pharmacists. State chemists performed the chemicaltoxicological analysis
Milošević-Georgiev Andrijana, Krajinović Dušanka, Manojlović Jelena, Ignjatović Svetlana, Majkić-Singh Nada   +4 more
doaj  

Metabolome Changes during In Vivo Red Cell Aging Reveal Disruption of Key Metabolic Pathways

iScience, 2020
Summary: Understanding the mechanisms for cellular aging is a fundamental question in biology. Normal red blood cells (RBCs) survive for approximately 100 days, and their survival is likely limited by functional decline secondary to cumulative damage to ...
Neema Jamshidi, Xiuling Xu, Katharina von Löhneysen, Katrin Soldau, Rob P. Mohney, Edward D. Karoly, Mike Scott, Jeffrey S. Friedman   +7 more
doaj   +1 more source

Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells

iScience
Summary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear.
Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Xu Li   +7 more
doaj   +1 more source

Tuberculostearic acid incorporated predictive model contributes to the clinical diagnosis of tuberculous meningitis

iScience, 2023
Summary: The conventional confirmation tests of tuberculous meningitis (TBM) are usually low in sensitivity, leading to high TBM mortality. Hence, sensitive methods for indicating the presence of bacilli are required.
Tsz Hei Fong, Wangpan Shi, Guohui Ruan, Siyi Li, Guanghui Liu, Leyun Yang, Kaibin Wu, Jingxian Fan, Chung Lam Ng, Yafang Hu, Haishan Jiang   +10 more
doaj   +1 more source

Improvement of the Biochemistry course for pharmacy students at Medical University Varna

, 2015
Research results on students` content regarding the basic biochemistry course of the `Pharmacy` programme at Medical University Varna are presented based on a three year survey (from 2011/2012 up to 2013/2014 academic year). The respondents comprised 80%
Ivanova, Diana; Medical university of Varna, Department of biochemistry molecular medicine and nutrigenomics, Galunska, Bistra; Medical university of Varna, Department of pharmaceutical technologies, Nachar, Milka; Medical university of Varna, Department of biochemistry molecular medicine and nutrigenomics, Pasheva, Milena; Medical university of Varna, Department of biochemistry molecular medicine and nutrigenomics, Kiselova-Kaneva, Yoana; Medical university of Varna, Department of biochemistry molecular medicine and nutrigenomics   +4 more
core   +1 more source

Deepening Undergraduate Students’ Thinking about Central Dogma through Problem-Based Learning

Education Sciences, 2023
A common belief among pre-medical and medical students is that biochemistry is not relevant to practicing medicine. The problem-based approach of case studies has been used in medical education to scaffold the application of content to clinical cases ...
Katherine Alberta Sharp, Rebecca McNall Krall, Jeffrey Chalfant   +2 more
doaj   +1 more source

Planning an Objective and Need Based Curriculum: The Logistics with Reference to the Undergraduate Medical Education in Biochemistry [PDF]

Journal of Clinical and Diagnostic Research, 2013
Purpose: The medical education is recently being transformed into several domains in order to adapt to the need and the value based academics which is required for the quality doctors who serve the community. Presently, the biochemistry curricula for
Ramesh Ramasamy, Niranjan Gopal, Srinivasan A R, Sathish Babu Murugaiyan   +3 more
doaj   +1 more source

A novel APA-based prognostic signature may predict the prognosis of lung adenocarcinoma in an East Asian population

iScience, 2023
Summary: The role of alternative polyadenylation (APA) in tumor development is becoming increasingly evident, but the impact of APA events on the prognosis of LUAD patients is unclear.
Wendi Zhang, Yang Hu, Min Qian, Liping Mao, Yanqiong Yuan, Huiwen Xu, Yiran Liu, Anni Qiu, Yan Zhou, Yang Dong, Yutong Wu, Qiong Chen, Xiaobo Tao, Tian Tian, Lei Zhang, Jiahua Cui, Minjie Chu   +16 more
doaj   +1 more source

Biochemometry identifies ostruthin as pluripotent antimicrobial and anthelmintic agent from masterwort

iScience, 2023
Summary: The root extract of Peucedanum ostruthium (PO-E) was identified as a promising antibacterial source from a screening of 158 extracts against Staphylococcus aureus.
Julia Zwirchmayr, Cristina D. Cruz, Ulrike Grienke, Päivi Tammela, Judith M. Rollinger   +4 more
doaj   +1 more source