Results 1 to 10 of about 552,503 (299)

Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications

Biomedicines, 2022
Natural antioxidants from fruits and vegetables, meats, eggs and fish protect cells from the damage caused by free radicals. They are widely used to reduce food loss and waste, minimizing lipid oxidation, as well as for their effects on health through ...
Sonia Losada-Barreiro, Zerrin Sezgin-Bayindir, Fátima Paiva-Martins, Carlos Bravo-Díaz   +3 more
doaj   +4 more sources

Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology

iScience, 2020
Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been used in different areas. Compared with protein enzymes, catalytic nucleic acids are programmable in structure, easy to modify, and more stable especially for ...
Lingzi Ma, Juewen Liu
doaj   +3 more sources

Chitosan from shrimp shell waste as a carrier for frankincense nanoparticles with enhanced antimicrobial activity [PDF]

Scientific Reports
This study focuses on the sustainable extraction of chitosan from shrimp shell waste and its application in developing frankincense-loaded chitosan nanoparticles with enhanced antimicrobial efficacy. Chitosan was extracted through demineralization with 4%
Habiba A. Ahmed, Zeinab A. Salama, Abeer E. Abd El-Wahab, Ahmed M. Aboul-Enein, Amr Nassrallah   +4 more
doaj   +2 more sources

Structural studies of the shortest extended synaptotagmin with only two C2 domains from Trypanosoma brucei

iScience, 2021
Summary: Extended synaptotagmins (E-Syts) localize at membrane contact sites between the endoplasmic reticulum (ER) and the plasma membrane to mediate inter-membrane lipid transfer and control plasma membrane lipid homeostasis.
Emma Stepinac, Nicolas Landrein, Daria Skwarzyńska, Patrycja Wójcik, Johannes Lesigang, Iva Lučić, Cynthia Y. He, Mélanie Bonhivers, Derrick R. Robinson, Gang Dong   +9 more
doaj   +1 more source

Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase

iScience, 2022
Summary: Pharmacological activation of the E3 ligase Parkin represents a rational therapeutic intervention for the treatment of Parkinson’s disease.
Evgeny Shlevkov, Paramasivam Murugan, Dan Montagna, Eric Stefan, Adelajda Hadzipasic, James S. Harvey, P. Rajesh Kumar, Sonya Entova, Nupur Bansal, Shari Bickford, Lai-Yee Wong, Warren D. Hirst, Andreas Weihofen, Laura F. Silvian   +13 more
doaj   +1 more source

Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

iScience, 2022
Summary: BRCA1 maintains genome stability by promoting homologous recombination (HR)-mediated DNA double-strand break (DSB) repair. Mutation of mouse BRCA1-S1152, corresponding to an ATM phosphorylation site in its human counterpart, resulted in ...
Leilei Qi, Reka Chakravarthy, Monica M. Li, Chu-Xia Deng, Rong Li, Yanfen Hu   +5 more
doaj   +1 more source

ProtSeq: Toward high-throughput, single-molecule protein sequencing via amino acid conversion into DNA barcodes

iScience, 2022
Summary: We demonstrate early progress toward constructing a high-throughput, single-molecule protein sequencing technology utilizing barcoded DNA aptamers (binders) to recognize terminal amino acids of peptides (targets) tethered on a next-generation ...
Jessica M. Hong, Michael Gibbons, Ali Bashir, Diana Wu, Shirley Shao, Zachary Cutts, Mariya Chavarha, Ye Chen, Lauren Schiff, Mikelle Foster, Victoria A. Church, Llyke Ching, Sara Ahadi, Anna Hieu-Thao Le, Alexander Tran, Michelle Dimon, Marc Coram, Brian Williams, Phillip Jess, Marc Berndl, Annalisa Pawlosky   +20 more
doaj   +1 more source

Redox manipulation of enzyme activity through physiologically active molecule

iScience, 2021
Summary: The effective utility of physiologically active molecules is crucial in numerous biological processes. However, the regulation of enzyme functions through active substances remains challenging at present.
Dao Lin, Yuhe Kan, Liang Yan, Yongqi Ke, Yang Zhang, Hang Luo, Xinjing Tang, Xiangjun Li, Yujian He, Li Wu   +9 more
doaj   +1 more source

Correction: Chitosan from shrimp shell waste as a carrier for frankincense nanoparticles with enhanced antimicrobial activity [PDF]

Scientific Reports
Habiba A. Ahmed, Zeinab A. Salama, Abeer E. Abd El-Wahab, Ahmed M. Aboul-Enein, Amr Nassrallah   +4 more
doaj   +2 more sources

Application of Postmortem Biochemistry Analysis in Forensic Medicine

Fayixue Zazhi, 2021
In recent years, postmortem biochemistry analysis has gradually been applied to forensic practice, providing objective evidence for health conditions before death, disease pathophysiological processes and forensic diagnosis of postmortem interval and ...
ZHU Bao-li, CAO Zhi-peng
doaj   +1 more source