Results 11 to 20 of about 580,532 (253)

Identification and characterization of andalusicin: N-terminally dimethylated class III lantibiotic from Bacillus thuringiensis sv. andalousiensis

iScience, 2021
Summary: Lanthipeptides, ribosomally synthesized and post-translationally modified peptides (RiPPs), can be divided into five classes based on their structures and biosynthetic pathways. Class I and II lanthipeptides have been well characterized, whereas
Anastasiia Grigoreva, Julia Andreeva, Dmitry Bikmetov, Anastasiia Rusanova, Marina Serebryakova, Andrea Hernandez Garcia, Darya Slonova, Satish K. Nair, Guy Lippens, Konstantin Severinov, Svetlana Dubiley   +10 more
doaj   +1 more source

SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis

iScience, 2022
Summary: SHP2 is the first oncogenic tyrosine phosphatase encoded by PTPN11, which plays a significant regulatory role in cancer and inflammation-related diseases. Although SHP2 allosteric inhibitors have been used in phase I/II clinical trials for solid
Meijing Wang, Tinghan Li, Zijun Ouyang, Kai Tang, Yuyu Zhu, Chenglin Song, Haiyan Sun, Bin Yu, Xiaoyun Ji, Yang Sun   +9 more
doaj   +1 more source

Mechanistic and functional aspects of the Ruminococcin C sactipeptide isoforms

iScience, 2023
Summary: In a scenario where the discovery of new molecules to fight antibiotic resistance is a public health concern, ribosomally synthesized and post-translationally modified peptides constitute a promising alternative.
Lama Shamseddine, Clarisse Roblin, Iris Veyrier, Christian Basset, Lisa De Macedo, Anne Boyeldieu, Marc Maresca, Cendrine Nicoletti, Gaël Brasseur, Sylvie Kieffer-Jaquinod, Élise Courvoisier-Dezord, Agnès Amouric, Philippe Carpentier, Nathalie Campo, Mathieu Bergé, Patrice Polard, Josette Perrier, Victor Duarte, Mickael Lafond   +18 more
doaj   +1 more source

Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells

iScience, 2023
Summary: Chemically modified mRNAs hold great potential for therapeutic applications in vivo. Currently, the base modification scheme largely preserves the canonical Watson-Crick base pairing, thus missing one mode of mRNA modulation by altering its ...
Meng Zhang, Nilmani Singh, Mary Elisabeth Ehmann, Lining Zheng, Huimin Zhao   +4 more
doaj   +1 more source

A brief history of RT-PCR and our laboratory experience with SARS-CoV-2 analyses using RT-PCR

Jurnal Teknologi Laboratorium, 2022
Polymerase Chain Reaction (PCR) is in vitro replication that allows accelerated amplification of certain sequences in small DNA fragments. A sensitive technique, only traces of DNA are needed for PCR to produce enough copies to be analyzed.
Naci Omer Alayunt
doaj   +1 more source

Quinoa husk peptides reduce melanin content via Akt signaling and apoptosis pathways

iScience, 2023
Summary: To improve the treatment of pigmentation disorders, looking for natural and safe inhibitors of melanin synthesis has become an area of research interest. The quinoa husk peptides reportedly elicit various biological activities (e.g., anti-cancer,
Caijing Han, Bingjie Lin, Xinyu Huang, Zhaojie Mao, Xiaoting Kong, Lei Fang, Peng Xue, Anning Wang, Fengxiang Zhang   +8 more
doaj   +1 more source

A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signaling

iScience, 2021
Summary: Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling).
Juliane Lokau, Yvonne Garbers, Joachim Grötzinger, Christoph Garbers   +3 more
doaj   +1 more source

Oxidative stress biomarkers and chondrocyte apoptosis as predictors of postoperative outcomes in osteonecrosis of the femoral head [PDF]

Journal of Medical Biochemistry
Background: Osteonecrosis of the femoral head (ONFH) is a progressive disease where oxidative stress and chondrocyte apoptosis contribute to cartilage degeneration and postoperative complications. Identifying reliable biochemical markers is essential for
Hu Chia-Jui, Song Ming, Yu Lai, Zeng Guanfei   +3 more
doaj   +1 more source

The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling

iScience, 2022
Summary: Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death.
Emmanuel Laplantine, Christine Chable-Bessia, Anne Oudin, Jitendryia Swain, Adèle Soria, Peggy Merida, Manon Gourdelier, Sarra Mestiri, Indira Besseghe, Erwan Bremaud, Aymeric Neyret, Sebastien Lyonnais, Cyril Favard, Philippe Benaroch, Mathieu Hubert, Olivier Schwartz, Maryse Guerin, Anne Danckaert, Elaine Del Nery, Delphine Muriaux, Robert Weil   +20 more
doaj   +1 more source

Redox manipulation of enzyme activity through physiologically active molecule

iScience, 2021
Summary: The effective utility of physiologically active molecules is crucial in numerous biological processes. However, the regulation of enzyme functions through active substances remains challenging at present.
Dao Lin, Yuhe Kan, Liang Yan, Yongqi Ke, Yang Zhang, Hang Luo, Xinjing Tang, Xiangjun Li, Yujian He, Li Wu   +9 more
doaj   +1 more source