Results 131 to 140 of about 27,360,159 (343)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Group mentoring for junior medical students: perceptions of mentees and mentors

Revista Brasileira de Educação Médica
Entering medical school can be associated with a number of difficulties that can hinder students' performance. Mentoring programs are designed to help students circumvent difficulties and improve their learning and personal development. The current study
Maria de Fátima Aveiro Colares, Margaret de Castro, Cristiane Martins Peres, Afonso Diniz Costa Passos, José Fernando de Castro Figueiredo, Maria de Lourdes Veronese Rodrigues, Luiz Ernesto de Almeida Troncon   +6 more
doaj   +1 more source

Medical Data Architecture Prototype Development - Summary of Recent Work and Proposed Ideas for Upcoming Work [PDF]

The Medical Data Architecture (MDA) project supports the Exploration Medical Capability (ExMC) risk to minimize or reduce the risk of adverse health outcomes and decrements in performance due to in-flight medical capabilities on human exploration ...
Burian, B., Krihak, M., Schmitt, B., Shaw, T., Shetye, S.   +4 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Development of a Scale Measuring Medical Mistrust Among Medical and Healthcare Students and Providers

Journal of Multidisciplinary Healthcare
Hung-Chang Liao,1,2 Ya-Huei Wang3– 5 1Department of Health Policy and Management, Chung Shan Medical University, Taichung, Taiwan; 2Department of Medical Management, Chung Shan Medical University Hospital, Taichung, Taiwan; 3Department of Applied Foreign
Liao HC, Wang YH
doaj  

Formação e seleção de docentes para currículos inovadores na graduação em saúde

Revista Brasileira de Educação Médica
A expansão do número de vagas no ensino superior, especialmente na área da saúde, deu-se principalmente às custas do setor privado e sob as recomendações das Diretrizes Curriculares Nacionais.
José Lúcio Martins Machado, Valéria Menezes Machado, Joaquim Edson Vieira   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integrating medical simulation programs into the Turkish undergraduate medical curriculum

Advances in Medical Education and Practice, 2016
Dilek Kitapçıoğlu, Mehmet Emin Aksoy Medical Education Department, Faculty of Medicine, Acibadem University, CASE - Center of Advanced Simulation and Education, Istanbul, TurkeyThe letter by Ah-kee and Khan1 arguing that a mandatory year for ...
Kitapçıoğlu D, Aksoy ME
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source