Results 31 to 40 of about 4,163,570 (313)

A Bayesian adaptive marker‐stratified design for molecularly targeted agents with customized hierarchical modeling [PDF]

, 2019
It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect ...
Cao, Sha, Guo, Beibei, Han, Yan, Zang, Yong, Zhang, Chi   +4 more
core   +3 more sources

Questionnaire survey on medical futility and termination of resuscitation in cardiac arrest patients among emergency physicians in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi, 2019
INTRODUCTION The perceptions of medical futility and decisions about termination of resuscitation (TOR) for out-of-hospital cardiac arrest (OHCA) are highly heterogeneous and dependent on the practice of the attending emergency physicians.
CW So, C. Lui, K. Tsui, K. Chan, Alex KK Law, YK Wong, T. Li, CL Wong, SC Leung   +8 more
semanticscholar   +1 more source

On Charlie Gard: Ethics, Culture, and Religion [PDF]

, 2018
The 2017 story of Charlie Gard is revisited. Upon the British High Court’s ruling in favor of the physicians that the infant should be allowed to die without the experimental treatment, the view of the public as well as the opinions of bioethicists and ...
Lee, Marvin J. H.
core   +1 more source

Ethical Issues in Family Practice: Medical Futility — The debate

South African Family Practice, 2004
No abstract available.
D. Knapp van Bogaert, G.A. Ogunbanjo
doaj   +1 more source

Withdrawing Medically Futile Treatment [PDF]

Journal of Oncology Practice, 2009
Physicians confront clinical and ethical dilemmas when their patients wish to continue treatments they have deemed futile; they must consider ethical obligations in deciding whether treatment should be withdrawn and in transferring patients from futile treatment to supportive care.
Dianna S, Howard, Timothy M, Pawlik
openaire   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Knowledge and Practice of Medical Futility by Intensive Care Professionals

Revista Latinoamericana de Bioética
Recent technical and scientific advances in Intensive Care Units (ICUs) have introduced new ethical challenges for health professionals, particularly concerning the practice of medical futility. This study aimed to assess ICU professionals’ knowledge of
Sara Fernanda Hilgert, Luiz Bonamigo, Antuani Rafael Baptistella   +2 more
doaj   +1 more source

Doing more does not mean doing better: the FADOI contribution to the Slow Medicine program for a sustainable and wise healthcare system

Italian Journal of Medicine, 2015
Consistently with its own vision on the necessity to implement a sustainable and frugal medicine, in 2013 the Italian Federation of Associations of Hospital Doctors in Internal Medicine (FADOI) decided to adhere to the Slow Medicine program entitled ...
Luigi Lusiani, Roberto Frediani, Roberto Nardi, Andrea Fontanella, Mauro Campanini   +4 more
doaj   +1 more source

Statistics, ethics, and probiotica

, 2008
A randomized clinical trial comparing an experimental new treatment to a standard therapy for a life-threatening medical condition should be stopped early on ethical grounds, in either of the following scenarios: (1) it has become overwhelmingly clear ...
Gill, Richard D.
core   +5 more sources

Sugar‐Armored Pesticides: Self‐Assembled System for Enhanced Foliar Adhesion and Sustained Delivery of Hydrophobic Antimicrobials Against Bacterial Diseases

Advanced Science, EarlyView.
This study develops a sugar‐armored, self‐assembled pesticide delivery system that enhances foliar adhesion, provides sustained release, effectively disrupts biofilms, and demonstrates superior bactericidal activity for improved disease control.
Jinghan Yang, Juan Liu, Xiaohui Wang, Peiyi Wang   +3 more
wiley   +1 more source