Results 61 to 70 of about 4,163,570 (313)

Continuous outcome estimation in N‐of‐1 trials for accelerated decision‐making

Epilepsia, EarlyView.
Abstract Objective N‐of‐1 trials aim to determine the therapeutic effect for a single individual. This individualized approach necessitates collecting multiple data points over time through repeated alternating periods of active treatment and a comparator or control condition.
Victoria Defelippe, František Bartoš, Eric‐Jan Wagenmakers, Kees P. J. Braun, Floor E. Jansen, Willem M. Otte   +5 more
wiley   +1 more source

Stigma, attitude, and knowledge of epilepsy in Italy: A survey on 1159 subjects

Epilepsia Open, EarlyView.
Abstract Objective Stigma remains a major determinant of impaired quality of life (QoL) in people with epilepsy (PwE). We aimed to investigate perceptions of epilepsy‐related stigma in the Italian general population, assess knowledge of epilepsy and seizure first aid, and identify factors associated with stigmatizing attitudes.
Marina Romozzi, Federico Tosto, Raffaele Turano, Lapo Sbrenna, Davide Chiffi, Flavia Bianchi, Vincenzo Trigila, Catello Vollono, Giovanni Assenza, Mario Tombini, Paolo Calabresi, Sonia Di Tella, Luigi Francesco Iannone   +12 more
wiley   +1 more source

The persistent vegetative state: legal and ethical issues [PDF]

, 1995
Recent advances in technology and medical expertise have enabled doctors to prolong the lives of many severely injured patients who only a few years ago would have died from their injuries. The prolongation of life by such measures has raised many legal,
Dobson, Rosemary
core  

Nonavalent HPV vaccine to prevent recurrent anal or vulvar high‐grade squamous intraepithelial lesions (VIVA trial): A randomized, double‐blind, placebo‐controlled trial

International Journal of Cancer, EarlyView.
What's New? Anal and vulvar high‐grade squamous intraepithelial lesions (HSILs) frequently recur following treatment. Additional genital and anal procedures, however, can be distressing for patients and are potentially disfiguring. This trial assessed whether the 9‐valent human papillomavirus (9vHPV) vaccine reduces HSIL recurrence risk or HPV ...
Helen C. Stankiewicz Karita, Amalia S. Magaret, David R. Doody, Jeffrey T. Schouten, Constance Mao, Warner K. Huh, Verena S. Grieco, Matthew A. Seymour, Dana Varon, Kelly H. Shrader, Long Fu Xi, Denise A. Galloway, Anna Wald, Margaret M. Madeleine   +13 more
wiley   +1 more source

Induced abortion in the world: 3. In search of a minimum common ground

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The rising worldwide trend toward legalization of termination of pregnancy has been accompanied by increased polarization around abortion. Two opposite broad coalitions emerged from this confrontation, generally known as the “pro‐life” and “pro‐choice” movements. The basic issue for pro‐life advocates is that the protection of “innocent, human
Giuseppe Benagiano, Kristina Gemzell‐Danielsson, Marwan Habiba, Salvatore Mancuso, Shantha Shantha‐Kumari   +4 more
wiley   +1 more source

Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT

Efficacy and Mechanism Evaluation, 2020
Background: Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction and is independently associated with adverse outcomes.
Peter J McCartney, Hany Eteiba, Annette M Maznyczka, Margaret McEntegart, John P Greenwood, Douglas F Muir, Saqib Chowdhary, Anthony H Gershlick, Clare Appleby, James M Cotton, Andrew Wragg, Nick Curzen, Keith G Oldroyd, Mitchell Lindsay, J Paul Rocchiccioli, Aadil Shaukat, Richard Good, Stuart Watkins, Keith Robertson, Christopher Malkin, Lynn Martin, Lynsey Gillespie, Thomas J Ford, Mark C Petrie, Peter W Macfarlane, R Campbell Tait, Paul Welsh, Naveed Sattar, Robin A Weir, Keith A Fox, Ian Ford, Alex McConnachie, Colin Berry   +32 more
doaj   +1 more source

Conditional Estimation in Two-stage Adaptive Designs

, 2017
We consider conditional estimation in two-stage sample size adjustable designs and the following bias. More specifically, we consider a design which permits raising the sample size when interim results look rather promising, and, which keeps the ...
Broberg, Per, Miller, Frank
core   +1 more source

Possible predicative role of electrical risk score on transcatheter aortic valve replacement outcomes in older patients. preliminary data [PDF]

, 2018
Background:Transcatheter aortic valve replacement (TAVR) is an effective procedure capable to change the natural history of the degenerative aortic valve stenosis.
DI IORIO, Claudia, Fabietti, Marcella, Magri', Damiano, Mancone, Massimo, Mariani, MARCO VALERIO, Mastropietri, Fabiola, Moscucci, Federica, Parrotta, Ilaria, Piccirillo, Gianfranco, Sardella, Gennaro   +9 more
core   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Inpatient palliative chemotherapy is associated with high mortality and aggressive end-of-life care in patients with advanced solid tumors and poor performance status

BMC Palliative Care, 2019
Background The benefit of palliative chemotherapy (PC) in patients with advanced solid tumors and poor performance status (ECOG-PS) has not been prospectively validated, which makes treatment decision challenging.
Vitor Fiorin de Vasconcellos, Renata RCC Bonadio, Guilherme Avanço, Marcelo Vailati Negrão, Rachel Pimenta Riechelmann   +4 more
doaj   +1 more source