Results 101 to 110 of about 2,823,528 (278)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Wartime Army Medical Laboratory Activities [PDF]

American Journal of Public Health and the Nations Health, 1947
openaire   +3 more sources

Implementing a quality management system using good clinical laboratory practice guidelines at KEMRI-CMR to support medical research [PDF]

, 2018
Horace Gumba, Joseph Waichungo, Brett Lowe, Alfred Mwanzu, Robert Musyimi, Johnstone Thitiri, Caroline Tigoi, Martin Kamui, James A. Berkley, Ronald Ngetich, Susan Kavai, Samuel Kariuki   +11 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Shaping the future of medical laboratory practices in Somaliland: a review of the current standards

Discover Applied Sciences
Medical laboratory science has an acknowledged pivotal role in evidence-based practices and patient-centered care, informing clinical decision-making for precise diagnosis and treatment.
Omar Abdulkarim Saeed Alhammadi, Zhinya Kawa Othman, Ephraim Ikpongifono Udokang, Tayaba Sarfraz, Olalekan John Okesanya, Jerico Bautista Ogaya, Don Eliseo Lucero-Prisno   +6 more
doaj   +1 more source

Medical Schools and Laboratories [PDF]

Science, 1916
openaire   +2 more sources

Clinical and laboratory findings of patients with the possible diagnosis of influenza hospitalized in affiliated hospitals of Babol University of Medical Sciences, 2015-2016 [PDF]

, 2018
Mostafa Javanian, Arefeh Babazadeh, Soheil Ebrahimpour, Mehran Shokri, Masomeh Bayani   +4 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Measurement uncertainty in laboratory medicine: the bridge between medical and industrial metrology

, 2019
Abdurrahman Coşkun, Berrin Berçık Inal, Muhittin A. Serdar   +2 more
openalex   +1 more source