Results 141 to 150 of about 10,544,432 (365)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Responding to the needs of medical laboratory professionals: The CSMLS Mental Health Toolkit

Journal of Community Safety and Well-Being
Canadian Society for Medical Laboratory Science (CSMLS) is Canada’s national certifying body and professional society for medical laboratory professionals. Their research revealed increasing levels of workplace stress among their membership and concerns
Rosina Mete, Brandon Djukic, Christine Nielsen   +2 more
doaj   +1 more source

A Laboratory Manual of Organic Chemistry for Medical Students. [PDF]

, 1917
M. Abigail Steel
openalex   +1 more source

Skylab mobile laboratory [PDF]

The Skylab mobile laboratory was designed to provide the capability to obtain necessary data on the Skylab crewmen 30 days before lift-off, within 1 hour after recovery, and until preflight physiological baselines were reattained.
Larue, M. A., Primeaux, G. R.
core   +1 more source

A Survey of Laboratory Programs for First Year Medical Students [PDF]

, 1971
Basic science courses offered to freshmen medical students have been traditionally taught by didactic presentations and laboratory work. Various factors have prompted many departments to either markedly reduce the time allotted for the traditional, but ...
Guyer, Kenneth E., Jr., Poland, James L., Seibel, Hugo R.   +2 more
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

THE NEED OF MEDICAL COOPERATION IN LABORATORY WORK.ADDRESS OF CHAIRMAN OF THE SECTION ON PATHOLOGY AND PHYSIOLOGY, AT THE FIFTY-EIGHTH ANNUAL SESSION OF THE AMERICAN MEDICAL ASSOCIATION AT ATLANTIC CITY, JUNE, 1907. [PDF]

, 1907
Walter L. Bierring
openalex   +1 more source

Exploring unlikely errors using video games: An example in number entry research [PDF]

, 2012
A common and important feature of many safety critical interactive devices is number entry. In hospitals, number entry takes the form of setting drug parameters such as doses, volumes, etc. There are several ways a number entry interface can be designed -
Cox, Anna, Curzon, Paul, Iacovides, Ioanna, Oladimeji, Patrick, Thimbleby, Harold   +4 more
core  

Fragmentation cross sections of Fe^{26+}, Si^{14+} and C^{6+} ions of 0.3-10 A GeV on CR39, polyethylene and aluminum targets

, 2008
New measurements of the total and partial fragmentation cross sections in the energy range 0.3-10 A GeV of Fe^{26+}, Si^{14+} and C^{6+} beams on polyethylene, CR39 and aluminum targets are presented.
A. Kumar, A.R. Margiotta, E. Medinaceli, G. Giacomelli, G. Mandrioli, G. Sirri, I.E. Qureshi, L. Patrizii, M. Spurio, S. Cecchini, S. Manzoor, T. Chiarusi, V. Popa, V. Togo., Z. Sahnoun   +14 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source