Results 41 to 50 of about 6,578,863 (285)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Multi-omics and machine learning-based profiling of severity signatures in Mycoplasma pneumoniae infection in children

iScience
Summary: Mycoplasma pneumoniae pneumonia (MPP) is a common respiratory infection in children; however, the mechanisms driving its progression to severe disease remain poorly understood.
Guiqiu Li, Ying Wei, Wenzheng Wang, Zhili Hu, Qiaowen Yang, Lili He, Yun Gao, Xiulan Lai   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Translocation across a human enteroid monolayer by zoonotic Streptococcus suis correlates with the presence of Gb3-positive cells

iScience
Summary: Streptococcus suis is a zoonotic pathogen that can cause meningitis and septicaemia. The consumption of undercooked pig products is an important risk factor for zoonotic infections, suggesting an oral route of infection.
Thomas J. Roodsant, Kees C.H. van der Ark, Constance Schultsz   +2 more
doaj   +1 more source

Comparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh: Real-World Data

International Journal of General Medicine, 2023
Figen Sarıgül Yıldırım,1 Aslıhan Candevir,2 Sıla Akhan,3 Selçuk Kaya,4 Mehmet Çabalak,5 Gülden Ersöz,6 Dilara İnan,7 Nurgül Ceren,8 İlkay Karaoğlan,9 Tuba Damar Çakırca,10 Şafak Özer Balin,11 Sevil Alkan,12 ...
Sarıgül Yıldırım F, Candevir A, Akhan S, Kaya S, Çabalak M, Ersöz G, İnan D, Ceren N, Karaoğlan İ, Damar Çakırca T, Özer Balin Ş, Alkan S, Kandemir Ö, Üser Ü, Karabay O, Çelen MK   +15 more
doaj  

Perception of online and face to face microbiology laboratory sessions among medical students and faculty at Arabian Gulf University: a mixed method study

BMC Medical Education, 2022
Background The COVID-19 pandemic has impacted all spheres of society including medical education and healthcare systems. In response to the pandemic, there has been a transition in medical education practice from traditional forms of teaching to online ...
Ronni Mol Joji, Archana Prabu Kumar, Amer Almarabheh, Fazal K Dar, Abdel Halim Deifalla, Yasin Tayem, Abdulrahman Yusuf Ismaeel, Khalid Bindayna, Khaled Saeed Tabbara, Eman Farid, Mohd Shadab, Ali Al Mahmeed, Mohammad Shahid   +12 more
doaj   +1 more source

The Impact of Experiential Learning in Host-Pathogen Research on Medical Students’ Interests and Attitudes towards Microbiology and Immunology

Journal of Microbiology & Biology Education, 2021
There is a shortage of residents in the infectious diseases (IDs) specialty due to a lack of interest in this field. If the choice of an ID subspecialty is linked to medical school experiences, then how we teach microbiology and immunology could be a ...
Jorge Cervantes, Bo-Young Hong
doaj   +1 more source

Manifesto for medical research [PDF]

, 2015
The MRCG want to ensure there is a dynamic medical research environment in Ireland. Ensuring priority investment for medical research will help to deliver patient care, public health service transformation and economic and enterprise development.
Medical Research Charities Group
core  

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Prevalence of aac(3)-IIa, aph(3)-Ia and ant(2)- Ia Genes among Uropathogenic Escherichia Coli Isolates

Medical Laboratory Journal, 2014
Background and Objective: Escherichia coli, one of the most common causative agents of urinary tract infections (UTIs) acquired from community and hospital, has developed multiple resistances to various antibiotics such as aminoglycosides.
GH Goudarzi, P MSc of Microbiology, Department of Microbiology, School of Medicine, Lorestan University of Medical, M Lashkarara   +2 more
doaj