Results 111 to 120 of about 59,810 (337)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ariel - Volume 6 Number 1 [PDF]

, 1973
Editors John Lammie Curt Cummings Frank Chervenak J.D. Kanofsky Mark Dembert Entertainment Robert Breckenridge Joe Conti Gary Kaskey Photographer Larry Glazerman Overseas Editor Mike Sinason Circulation Jay Amsterdam Humorist Jim McCann Staff Ken Jaffe ...
Brashear, David S., Brener, Harry, Chervenak, Frank, Cummings, Curt, Faust, Halley S., Kanofsky, J.D., Lammie, John, Massimino, Fred, Sklaroff, Bob   +8 more
core   +1 more source

The influence of artificial intelligence on the work of the medical physicist in radiotherapy practice: a short review. [PDF]

BJR Open, 2023
Fiagbedzi E, Hasford F, Tagoe SN.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The updated ESTRO core curricula 2011 for clinicians, medical physicists and RTTs in radiotherapy/radiation oncology [PDF]

, 2012
Jesper Grau Eriksen, Andrew Beavis, Mary Coffey, J.W.H. Leer, Stefano Maria Magrini, Kim Benstead, T. Boelling, Marie Hjälm-Eriksson, Guy Kantor, B. Maciejewski, M. Mežeckis, Ângelo Oliveira, P. Thirion, Pavel Vítek, Dag Rune Olsen, T. Eudaldo, W. Enghardt, Pascal François, Cristina Garibaldi, Ben Heijmen, Mirjana Josipović, Tibor Major, S. Nikoletopoulos, Alex Rijnders, M.P.R. Waligórski, M. Wasilewska–Radwańska, L. Mullaney, A. Boejen, Aude Vaandering, Guy Vandevelde, Christine Verfaillie, Richard Pötter   +31 more
openalex   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Beam Data Validation during Transition from Flattened to Unflattened Beams in IMRT and VMAT Delivery: An Experimental Study

Journal of Clinical and Diagnostic Research
Introduction: The commissioning process for Intensity-Modulated Radiotherapy (IMRT) and RapidArc is very rigorous and tedious. It involves manifold beam data measurement, Quality Assurance (QA) and acceptance testing of different parts of Linear ...
Pradeep Goswami, Punam Kumari, Brijesh Goswami, Rakesh Kumar Jain, Suresh Yadav, S Choudhary, Asiya Hilal, Kishore Singh   +7 more
doaj   +1 more source

Medical physicist certification and training program accreditation. [PDF]

Health Technol (Berl), 2022
Ibbott GS, Chougule A, Damilakis J, Tabakov S, Wu RK, Orton CG, Kron T.   +6 more
europepmc   +1 more source