Results 71 to 80 of about 802,596 (333)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A low background Micromegas detector for the CAST experiment

, 2005
A low background Micromegas detector has been operating on the CAST experiment at CERN for the search of solar axions during the first phase of the experiment (2002-2004).
Abbon, P., Andriamonje, S., Aune, S., Besin, D., Cazaux, S., Contrepois, P., Dafni, T., Decker, T., Duportail, N., Fanourakis, G., Geralis, T., Giganon, A., Giomataris, I., Gros, M., Hill, R., Irastorza, I. G., Kousouris, K., Morales, J., Pivovaroff, M., Riallot, M., Ribas, E. Ferrer, Soufli, R., Zachariadou, K., Zaffanela, G.   +23 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Emergent properties hidden in plane view: Strong electronic correlations at oxide interfaces

, 2014
Finding new collective electronic states in materials is one of the fundamental goals of condensed matter physics. Atomic-scale superlattices formed from transition metal oxides are a particularly appealing hunting ground for new physics.
Chakhalian, Jak, Freeland, John W., Millis, Andrew J., Panagopoulos, Christos, Rondinelli, James M.   +4 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Radiology education in Europe: Analysis of results from 22 European countries. [PDF]

, 2017
AimTo assess the state of radiology education across Europe by means of a survey study.MethodsA comprehensive 23-item radiology survey was distributed via email to the International Society of Radiology members, national radiological societies ...
Dillon, William P, Lau, Lawrence, Lette, Miriam N Mikhail, Palkó, András, Rehani, Bhavya, Rehani, Madan M, Zhang, Yi C   +6 more
core  

Operational Experience and First Results with a Highly Granular Tungsten Analog Hadron Calorimeter

, 2011
Precision physics at future multi-TeV lepton colliders such as CLIC requires excellent jet energy resolution. The detectors need deep calorimeter systems to limit the energy leakage also for very highly energetic particles and jets.
Simon, Frank
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Virtual Mentoring for Medical Physicists: Results of a Global Online Survey

Journal of Medical Physics
Purpose: Medical physics professional development is limited in parts of the globe and can be aided by virtual mentoring. A global online perception survey was conducted to elucidate the characteristics of the preferred virtual mentoring program. Methods:
Jacob Van Dyk, Matt Jalink, L. John Schreiner, Robert Jeraj   +3 more
doaj   +1 more source

Crystals for high-energy calorimeters in extreme environments

, 2005
Scintillating crystals are used for calorimetry in several high-energy physics experiments. For many of them, performance has to be ensured in very difficult operating conditions, like a high radiation environment and large particle fluxes, which place ...
Nessi-Tedaldi, F.
core   +1 more source