Results 71 to 80 of about 532,296 (301)

First-generation migrants’ use of psychotropic medication in Northern Ireland: a record linkage study [PDF]

International Journal of Mental Health Systems, 2019
Abstract Purpose There is a recent and growing migrant population in Northern Ireland. However, rigorous research is absent regarding access to mental health care by different migrant groups. In order to address this knowledge gap, this study aimed to identify the relative use of psychotropic medication between the ...
Tania Bosqui, Dermot O’Reilly, Ari Väänänen, Kishan Patel, Michael Donnelly, David Wright, Ciara Close, Anne Kouvonen   +7 more
openaire   +6 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Secure Privacy Preserving Record Linkage of Large Databases by Modified Bloom Filter Encodings

International Journal of Population Data Science, 2017
Objective In most European settings, record linkage across different institutions has to be based on personal identifiers such as names, birthday or place of birth. To protect the privacy of research subjects, the identifiers have to be encrypted.
Rainer Schnell, Christian Borgs
doaj   +1 more source

Evaluation of the effectiveness of the Family Nurse Partnership home visiting programme in first time young mothers in Scotland: a protocol for a natural experiment

International Journal of Population Data Science, 2020
Introduction: Individual, social and economic circumstances faced by young mothers can challenge a successful start in life for their children. Intervening early might enhance life chances for both mother and child.
Fiona V Lugg-Widger, Michael Robling, Mandy Lau, Shantini Paranjothy, Jill Pell, Julia Sanders, James White, Rebecca Cannings-John   +7 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A process to deduplicate individuals for regional chronic disease prevalence estimates using a distributed data network of electronic health records

Learning Health Systems, 2022
Introduction Learning health systems can help estimate chronic disease prevalence through distributed data networks (DDNs). Concerns remain about bias introduced to DDN prevalence estimates when individuals seeking care across systems are counted ...
Kenneth A. Scott, Sara Deakyne Davies, Rachel Zucker, Toan Ong, Emily McCormick Kraus, Michael G Kahn, Jessica Bondy, Matt F. Daley, Kate Horle, Emily Bacon, Lisa Schilling, Tessa Crume, Romana Hasnain‐Wynia, Seth Foldy, Gregory Budney, Arthur J. Davidson   +15 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effect of inpatient and outpatient care on treatment outcome in tuberculosis: a cohort study

Revista Panamericana de Salud Pública, 2018
Objective. To identify individual- and health services–related factors associated with deaths in subjects diagnosed with tuberculosis (TB). Methods. A nonconcurrent cohort study with passive follow-up was conducted using a probabilistic linkage method to
Marli S. Rocha, Gisele P. Oliveira, Valéria Saraceni, Fernanda P. Aguiar, Claudia M. Coeli, Rejane S. Pinheiro   +5 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Probabilistic data linkage: a case study of comparative effectiveness in COPD

Drugs in Context, 2013
Background: In this era of comparative effectiveness research, new, advanced techniques are being investigated by the research community to overcome the limitations of existing data sources.
Christopher M Blanchette, Mitch DeKoven, Ajita P De, Melissa Roberts   +3 more
doaj   +1 more source