Results 71 to 80 of about 1,190,273 (267)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Medical Records and their Recorders [PDF]

open access: yesClinical Medicine, 2003
Alan Glynn, OMP Jolobe
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

سلامت عمومی و استرس شغلی در كاركنان بخش مدارك پزشکی شاغل در بیمارستان‌های استان مازندران

open access: yesمدیریت اطلاعات سلامت, 2008
چكیده مقدمه: دست‌اندركاران حرفه‌های پزشكی به دلیل بر عهده داشتن مسؤولیت تأمین سلامت و درمان بیماران، تحت تأثیر عوامل متعدد استرس‌زا هستند. در این پژوهش میزان سلامت عمومی، استرس و عوامل استرس‌زا در كاركنان بخش مدارك پزشكی بیمارستان‌های استان مازندران ...
Azar Kabirzadeh   +4 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Data Documentation in Patients with Tuberculosis in Razi Hospital of Ghaemshahr, Iran

open access: yesمدیریت اطلاعات سلامت, 2013
Introduction: The health information system of hospitals depends on their medical records. Therefore, the detailed documentation, and maintenance of patient records can lead to timely diagnosis and effective treatment of diseases in any country, and ...
Sayede-Shahrebano Rashida   +1 more
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Assessment and Comparison of Hospital Information Systems in Isfahan Hospitals based on the Adjusted DeLone and McLean Model

open access: yesمدیریت اطلاعات سلامت, 2011
Introduction: Hospital Information Systems (HISs) have positive effects on patients' treatment process and organizational function. Therefore, it is necessary to evaluate the quality of services provided by such systems.
Sakeineh Saghaeiannejad Isfahani   +3 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

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