Results 81 to 90 of about 1,146,044 (291)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
مدیریت اطلاعات سلامت, 2011 Introduction: The entrance of the hospital is the reception and the communication with patients starts from this unit. The efficiency of the unit would be clear when all general rules including facilities and activities are controlled.
Fariba Ghahramani +2 more
doaj
Patient Satisfaction with Emergency Departments in Governmental General Hospitals, Kuwait
Journal of High Institute of Public Health, 2018 Background: Patient satisfaction is one of the essential determinants and indicators of the quality of health care and services delivery. Evaluation of patient satisfaction is considered an emergency department goal.
Saadoun F. Alazmi, Bashair A. Almutairi
doaj +1 more source
A Time and Motion Study of ICU Resident Work Practice in the Era of the Electronic Medical Record (EMR) [PDF]
, 2015 William D. Marino
openalex +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Comparison of Patient’s Rights in Developed Countries and Suggestion a Proper Model for Iran
مدیریت اطلاعات سلامت, 2011 Introduction: In health care, emphasis on basic human rights is especially important. Patient’s privacy protection becomes important when the human is exposed to shortcomings of social and health systems. This study was performed to compare the patient’s
Masoumeh Sarbaz, Khalil Kimiafar
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source