Results 71 to 80 of about 5,578,199 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

A human‐robot collaboration method for uncertain surface scanning

open access: yesCAAI Transactions on Intelligence Technology
Robots are increasingly expected to replace humans in many repetitive and high‐precision tasks, of which surface scanning is a typical example. However, it is usually difficult for a robot to independently deal with a surface scanning task with ...
Guanyi Zhao   +3 more
doaj   +1 more source

Computer-assisted Orthopaedic Surgery: Current State and Future Perspective

open access: yesFrontiers in Surgery, 2015
Introduced about two decades ago, computer-assisted orthopaedic surgery (CAOS) has emerged as a new and independent area, due to the importance of treatment of musculoskeletal diseases in orthopaedics and traumatology, increasing availability of ...
Guoyan eZheng, Lutz eNolte
doaj   +1 more source

The Relationship between Medical Students’ Assessment of Standardized Patients and Patient‐Physician Interaction Score [PDF]

open access: yes, 2019
When standardized patients (SPs) are used for educational purposes, the authenticity of role play and the quality of feedback are essential requirements of SPs.
Korean Medical Education Review (의학교육논단)
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

A Soft Sensor for Bleeding Detection in Colonoscopies

open access: yesAdvanced Intelligent Systems, 2022
Colonoscopies allow surgeons to detect common diseases, that is, colorectal cancer, ulcers, and other ailments. However, there is a risk of bleeding in the lower gastrointestinal (GI) tract while maneuvering endoscopes.
Arincheyan Gerald   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

The Perception of Character Education in Medical School [PDF]

open access: yes, 2020
The purpose of this study was to examine professors’ and students’ perceptions of curriculum that fosters character in medical school. ‘Character’ can be defined as a desirable personality and the ability to be a good person.
Korean Medical Education Review (의학교육논단)
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

A Review of Pneumatic Actuators Used for the Design of Medical Simulators and Medical Tools

open access: yesMultimodal Technologies and Interaction, 2019
Simulators have been traditionally used for centuries during medical gestures training. Nowadays, mechatronic technologies have opened the way to more evolved solutions enabling objective assessment and dedicated pedagogic scenarios.
Thibault Sénac   +6 more
doaj   +1 more source

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