Results 51 to 60 of about 163,257 (280)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Design, Implementation and Testing of Master Slave Robotic Surgical System [PDF]

Mehran University Research Journal of Engineering and Technology, 2015
The autonomous manipulation of the medical robotics is needed to draw up a complete surgical plan in development. The autonomy of the robot comes from the fact that once the plan is drawn up off-line, it is the servo loops, and only these, that control ...
Syed Amjad Ali, Amir Mahmood Soomro, Arbab Nighat Khizer   +2 more
doaj  

Real-time surgical instrument detection in robot-assisted surgery using a convolutional neural network cascade

Healthcare Technology Letters, 2019
Surgical instrument detection in robot-assisted surgery videos is an import vision component for these systems. Most of the current deep learning methods focus on single-tool detection and suffer from low detection speed.
Zijian Zhao, Tongbiao Cai, Faliang Chang, Xiaolin Cheng   +3 more
doaj   +1 more source

Dynamic parameter identification of upper-limb rehabilitation robot system based on variable parameter particle swarm optimisation

IET Cyber-systems and Robotics, 2020
To solve the problem of uncertain parameters in dynamic modelling of upper-limb rehabilitation robots, a dynamic parameter identification method based on variable parameters particle swarm optimisation (PSO) is developed.
Jin Lei Wang, Yafeng Li, Aimin An
doaj   +1 more source

Fast and Reliable Autonomous Surgical Debridement with Cable-Driven Robots Using a Two-Phase Calibration Procedure

, 2018
Automating precision subtasks such as debridement (removing dead or diseased tissue fragments) with Robotic Surgical Assistants (RSAs) such as the da Vinci Research Kit (dVRK) is challenging due to inherent non-linearities in cable-driven systems.
Canny, John, Fox, Roy, Goldberg, Ken, Krishnan, Sanjay, McKinley, Stephen, Seita, Daniel   +5 more
core   +1 more source

Empowering and assisting natural human mobility: The simbiosis walker [PDF]

, 2011
This paper presents the complete development of the Simbiosis Smart Walker. The device is equipped with a set of sensor subsystems to acquire user-machine interaction forces and the temporal evolution of user's feet during gait.
Frizera A., Frizera A., Frizera A., Neto A. Frizera, Oppenheim A. V., van Hook F. W., Wasson G., Widrow B., Winter D. A.   +8 more
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Navigation of mini swimmers in channel networks with magnetic fields [PDF]

, 2012
Controlled navigation of swimming micro robots inside fluid filled channels is necessary for applications in living tissues and vessels. Hydrodynamic behavior inside channels and interaction with channel walls need to be understood well for successful ...
Bezer, Ayse Ecem, Bezer, Ayşe Ecem, Temel, Fatma Zeynep, Yesilyurt, Serhat, Yeşilyurt, Serhat   +4 more
core   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Non-Rigid Map Fusion-Based RGB-Depth SLAM Method for Endoscopic Capsule Robots

, 2017
In the gastrointestinal (GI) tract endoscopy field, ingestible wireless capsule endoscopy is considered as a minimally invasive novel diagnostic technology to inspect the entire GI tract and to diagnose various diseases and pathologies.
Almalioglu, Yasin, Araujo, Helder, Konukoglu, Ender, Sitti, Metin, Turan, Mehmet   +4 more
core   +1 more source