Results 201 to 210 of about 338,390 (312)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Socioeconomic and economic factors affecting access and progression in medical schools: a systematic review and meta-analysis. [PDF]

J Educ Eval Health Prof
Arianpoor A, Pena A, Mercer A, Cox J, Lekkas D, Geronimo FR, Waldron H, Randal J, Dabner M, Lynagh M, Pather N, Shepherd N, Robb N, Berdin R, Wilkinson T, Hu W, Shulruf B, Huang PH.   +17 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Systematic review on occupational medicine training in European medical schools. [PDF]

Occup Med (Lond)
Larrosa M, Iguacel I, Bazas T, Braeckman L, Bulat P, Eglite M, Gehanno JF, Godderis L, Kudász F, Majery N, Reis P, Rodríguez-Jareño MC, Samant Y, Spreewers D, Gobba F, Martínez-Jarreta B.   +15 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Exploring UK medical schools' perception and intent for teaching on antimicrobial resistance and stewardship. [PDF]

JAC Antimicrob Resist
Lambert ZL, Weeks S, Dissanayake O, Boyd SE, Mughal N, Moore LSP, Pallett SJC.   +6 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Interventions to improve faculty well-being in medical schools: a scoping review. [PDF]

BMC Med Educ
Keskin DD, Koc D, Guven KM, Akoglu H, Altintas L, Sahiner M.   +5 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Uncovering Gaps in Obesity Medicine Competencies: Insights from Ten U.S. Medical Schools. [PDF]

Med Sci Educ
Pasarica M, Kushner RF, Leary AV, Agarwal M, Carpenter DA, Croniger C, Correa R, Grunvald E, Johnson MS, Loza J, Mock A, Olson A, Purnell J, Pfotenhauer K, Uhley V, Velasquez ST, Velazquez A, Smolarz BG.   +17 more
europepmc   +1 more source