Results 71 to 80 of about 571,968 (243)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Text messaging interventions are associated with reductions in HbA1c among patients with diabetes: a systematic review and meta-analysis

BMJ Open Diabetes Research & Care
Introduction Achieving optimal glycemic control remains challenging for many patients with diabetes. Text message-based interventions offer a scalable approach to enhance management.
Cynthia A Jackevicius, Dennis T Ko, Maneesh Sud, Baiju R Shah, Karen Tu, Candace D McNaughton, Lucas C Godoy, Neda Pirouzmand, Grace S Ko, Olivia Haldenby, Ayman Jubran   +10 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia

Journal for ImmunoTherapy of Cancer, 2022
James L Gulley, Thomas Hughes, Jennifer L Marté, Katherine R Calvo, Meghali Goswami, Christopher S Hourigan, Gege Gui, Laura W Dillon, Katherine E Lindblad, Julie Thompson, Janet Valdez, Dong-Yun Kim, Jack Y Ghannam, Karolyn A Oetjen, Christin B Destefano, Dana M Smith, Hanna Tekleab, Yeusheng Li, Pradeep Dagur, Jaydira del Rivero, Joanna Klubo-Gwiezdzinksa, Catherine Lai   +21 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Expression of alpha-smooth muscle actin in salivary mucoepidermoid and adenoid cystic carcinomas: A comparative immunohistochemical study

Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: يُعَد بروتينألفا أكتين العضلات الملساءعنصرًا محوريًا في عملية التليف. وقد أظهرت أورام الغدد اللعابية درجات متفاوتة من تعبير هذا البروتين نظرًا لاختلاف أدوار الخلايا العضلية الظهارية في تكوينها.
Shatha A. Alsalman, Ph.D Lecturer, Israa M. Alsudani, FIBMS professor, Sultan L. Al-Janabi, Medical Student   +2 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Developing a simulation-based learning model for acute medical education during COVID-19 pandemic with Simulation via Instant Messaging – Birmingham Advance (SIMBA)

BMJ Open Quality, 2022
Punith Kempegowda, Dengyi Zhou, Lucretia Thomas, Gregory Packer, John Ayuk, Jameela Sheikh, Eka Melson, Wentin Chen, Emma Ooi, Nia Evans, Dwi Delson, Meri Davitadze, Cai Ying Ng, Thia Hanania, Lucy Wallett, Parisha Blaggan, Georgia Morgan, Issy Allison, Carina Synn Cuen Pan, Gobeka Ponniah, Eloise Radcliffe, Alya Khashaba, Meghnaa Hebbar, Vinay Reddy-Koanu, Emily Akufo-Tetteh   +24 more
doaj   +1 more source

Improving student-faculty feedback: a medical student perspective

Advances in Medical Education and Practice, 2019
Osama Hamid, Natalie George, Varun KothariFaculty of Medicine, Imperial College London, London, UK Student-to-faculty feedback is an important tool in allowing the medical school to elicit student perception of the curriculum.
Hamid O, George N, Kothari V
doaj  

Medical student health

Academic Medicine, 1969
L W, Earley, D G, Johnson
openaire   +3 more sources