Results 161 to 170 of about 11,078,886 (299)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ontario Student Medical Education Research Conference (OSMERC) 2025

McGill Journal of Medicine
Ontario Medical Students Association (OMSA)
doaj   +1 more source

THE MEDICAL LIBRARY AND THE MEDICAL STUDENT.

Bulletin of the Medical Library Association, 1996
E C, Long, P G, Miller
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Neuregulin 4 in Insulin Resistance: Mechanisms, Controversies, and Therapeutic Perspectives

Diabetes, Metabolic Syndrome and Obesity
Zhiheng Qiao,1 Xiaocan Gai,1 Hongyang He,1 Guoliang Ji,1 Haixin Zhang,1 Shumin Liu21School of Graduate Students, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2Basic Medical College, Heilongjiang ...
Qiao Z, Gai X, He H, Ji G, Zhang H, Liu S   +5 more
doaj  

Medical Students and Ophthalmology [PDF]

British Journal of Ophthalmology, 1923
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Caricature of medical school professors.

A colour caricature by P. W. Eisdell Moore, depicting Professors from the School of Medicine. Left to right: Joseph Bernard Dawson, Eric F. D’Ath, Francis Gordon Bell, Charles Ernest Hercus, John Malcolm, William Percy Gowland, and Frederick Horace ...
Moore, Patrick Eisdell, 1918-
core  

Abstracts of the 4th International Student Medical Congress in Kosice

International Journal of Medical Students, 2013
International Journal of Medical Students
doaj  

Evaluation of medical students' awareness regarding acute rheumatic fever. [PDF]

PLoS One
Leblebici A, Almassri A, Berdiyeva N, Al-Hamati MAB, Uçar B.   +4 more
europepmc   +1 more source