Results 91 to 100 of about 2,307,247 (311)

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Medical Technology Under Proposals To Increase Competition in Health Care [PDF]

, 1982
A study by the Office of Technology Assessment (OTA) that considers the "implications for medical technology of increased competition in health care" (p. 3)
United States. Congress. Office of Technology Assessment.
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Opinion of students under dental technology programme, Medical university of varna On including in the curriculum a new course of training - Introduction to scientific research

, 2021
Modern university education involves both learning and research, and the research process itself needs to be accomplished with the participation of students.
Varneva, Mihaela; Faculty of Dental Medicine, Medical University Prof. Dr. P. Stoyanov – Varna
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Proceedings of the Uganda Medical Laboratory Technology Association (UMLTA)

, 2010
s of papers presentedTHE 28TH UMLTA & 5th FEAMLS SCIENTIFIC CONFERENCE THEME: “STRENGTHENING MEDICAL LABORATORY DELIVERY SYSTEM, -A GATEWAY TO ACHIEVING MILLENIUM DEVELOPMENT GOALS” Date: 18th - 19th November 2010 Venue: Churchill Courts Hotel ...
Uganda Medical Laboratory Technology Association, Federation of East African Association of Medical Laboratory Scientists   +1 more
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Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Technology: changing the focus of medical education?

, 2014
Sayinthen Vivekanantham, Rahul Prashanth Ravindran Faculty of Medicine, Imperial College London, London, UKWith technology advancing at such a fast rate, our ability to look up and use information quickly and efficiently has improved significantly.
Vivekanantham S, Ravindran RP
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User involvement in healthcare technology development and assessment: Structured literature review

, 2006
Purpose – Medical device users are one of the principal stakeholders of medical device technologies. User involvement in medical device technology development and assessment is central to meet their needs.
Ian Robinson, Shah, SGS, Syed Ghulam Sarwar Shah, Robinson, I   +3 more
core   +1 more source