Results 101 to 110 of about 2,321,590 (311)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Introduction : Technology and Medical Practice: Blood, Guts and Machines [PDF]

, 2010
"Modern medicine is highly technological, with advanced technologies being used in diagnosis and care to provide knowledge about the patient, define bodily states and structure everyday medical interventions and divisions of labour. Whilst supporting and
Berner, Boel,, Johnson, Ericka,
core  

Conduits to care: call lights and patients’ perceptions of communication

Journal of Multidisciplinary Healthcare, 2017
Mary Montie,1 Clayton Shuman,1 Jose Galinato,1 Lance Patak,2 Christine A Anderson,1 Marita G Titler1 1Department of Systems, Populations, and Leadership, School of Nursing, University of Michigan, Ann Arbor, MI, 2Department of Anesthesiology and Pain ...
Montie M, Shuman C, Galinato J, Patak L, Anderson CA, Titler MG   +5 more
doaj  

Innovative Medical Technology and the Treatment Decision-Making Process in Multiple Sclerosis: A Focus Group Study to Examine Patient Perspectives

Patient Preference and Adherence, 2021
L A Visser,1 M De Mul,2 W K Redekop1 1Health Technology Assessment, Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, the Netherlands; 2Health Services Management & Organization, Erasmus School of Health ...
Visser LA, De Mul M, Redekop WK
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conceptual proposal for LLM-generated FDG PET/CT follow-up reports in melanoma: a pilot study on model stability and blinded expert evaluation

Frontiers in Nuclear Medicine
PurposeOncological patients regularly undergo PET/CT re-staging, which requires a report that outlines their current disease status and highlights relevant changes compared to the previous PET/CT.
Wolfram A. Bosbach, Marie S. Heide, Nasir Gözlügöl, Dana Fatemeh, Foroud Aghapour Zangeneh, David Ventura, Philipp Schindler, Wolfgang Roll, Franziska Strunz, Federico Caobelli, Kuangyu Shi, Ali Afshar-Oromieh, Axel Rominger, Robert Seifert   +13 more
doaj   +1 more source

So, You Think You Have an Idea: A Practical Risk Reduction-Conceptual Model for Academic Translational Research

Bioengineering, 2017
Translational research for new drugs, medical devices, and diagnostics encompasses aspects of both basic science and clinical research, requiring multidisciplinary skills and resources that are not all readily available in either a basic laboratory or ...
John Schwartz, Christopher Macomber
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A narrative review of AI monitoring in postoperative pain management and functional rehabilitation for spinal cord injury

Frontiers in Neurology
Spinal cord injury (SCI) is a severe neurological condition often leading to significant disability, with causes including trauma, tumors, and spinal cord pathologies.
Xiaoqing Zhang, Jianping Sheng
doaj   +1 more source