Results 101 to 110 of about 15,500,666 (311)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Conduits to care: call lights and patients’ perceptions of communication

Journal of Multidisciplinary Healthcare, 2017
Mary Montie,1 Clayton Shuman,1 Jose Galinato,1 Lance Patak,2 Christine A Anderson,1 Marita G Titler1 1Department of Systems, Populations, and Leadership, School of Nursing, University of Michigan, Ann Arbor, MI, 2Department of Anesthesiology and Pain ...
Montie M, Shuman C, Galinato J, Patak L, Anderson CA, Titler MG   +5 more
doaj  

Innovative Medical Technology and the Treatment Decision-Making Process in Multiple Sclerosis: A Focus Group Study to Examine Patient Perspectives

Patient Preference and Adherence, 2021
L A Visser,1 M De Mul,2 W K Redekop1 1Health Technology Assessment, Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, the Netherlands; 2Health Services Management & Organization, Erasmus School of Health ...
Visser LA, De Mul M, Redekop WK
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Conceptual proposal for LLM-generated FDG PET/CT follow-up reports in melanoma: a pilot study on model stability and blinded expert evaluation

Frontiers in Nuclear Medicine
PurposeOncological patients regularly undergo PET/CT re-staging, which requires a report that outlines their current disease status and highlights relevant changes compared to the previous PET/CT.
Wolfram A. Bosbach, Marie S. Heide, Nasir Gözlügöl, Dana Fatemeh, Foroud Aghapour Zangeneh, David Ventura, Philipp Schindler, Wolfgang Roll, Franziska Strunz, Federico Caobelli, Kuangyu Shi, Ali Afshar-Oromieh, Axel Rominger, Robert Seifert   +13 more
doaj   +1 more source

So, You Think You Have an Idea: A Practical Risk Reduction-Conceptual Model for Academic Translational Research

Bioengineering, 2017
Translational research for new drugs, medical devices, and diagnostics encompasses aspects of both basic science and clinical research, requiring multidisciplinary skills and resources that are not all readily available in either a basic laboratory or ...
John Schwartz, Christopher Macomber
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A narrative review of AI monitoring in postoperative pain management and functional rehabilitation for spinal cord injury

Frontiers in Neurology
Spinal cord injury (SCI) is a severe neurological condition often leading to significant disability, with causes including trauma, tumors, and spinal cord pathologies.
Xiaoqing Zhang, Jianping Sheng
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source