Results 101 to 110 of about 2,307,247 (311)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

An investigation into the nature of verbal interactions during the practical training of medical technology students

, 1999
Magister Educationis - MEdvarious ideas have been propagated regarding the way people come to know in apprenticeship situations. The particular set of social practice theory that informs this study is that related to old-timers and newcomers.
Paulsen, Moira Catherina
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

СОМАТОМЕТРИЧЕСКАЯ ДИАГНОСТИКА АНДРОГЕННОЙ НЕДОСТАТОЧНОСТИ И ЕВНУХОИДИЗМА

Sovremennye Issledovaniâ Socialʹnyh Problem, 2015
Для выявления андрогенной недостаточности и евнухоидизма, как проявлений гипогонадизма, у мужчин в постпубертатном периоде наиболее простым и доступным методом является антропометрия, Среди основных антропометрических методик были неоднозначные ...
Anatoly Stepanovich Pulikov, Olga Leonidovna Moskalenko, Nikolai Petrovich Kuzenkov, Olga Isaevna Zaitseva   +3 more
doaj   +1 more source

Extended reality and healthcare practitioner well-being: scoping review

BJPsych Open
Background Extended reality may offer a convenient and effective method of increasing well-being within the wider healthcare workforce and particularly for those working in the mental health sector who are subject to high levels of stress because of ...
Holly Mould, Jonathan R. Abbas, Michael Loizou, Nick Culley, Sheena Asthana, Rohit Shankar, John Downey   +6 more
doaj   +1 more source

Information Technology and Medical Missteps: Evidence from a Randomized Trial [PDF]

We analyze the effect of a decision support tool designed to help physicians detect and correct medical "missteps". The data comes from a randomized trial of the technology on a population of commercial HMO patients.
Jonathan C. Javitt, James B. Rebitzer, Lonny Reisman   +2 more
core  

A look into medical innovations & medical devices in 2013-2017

, 2018
Introduction: Medical innovation has led to discoveries on how to prevent and cure many illnesses. As a result, millions of people have lived longer, healthier, and more productively.
Zhelyazkova, Desislava; Faculty of Medicine, Medical University of Varna, Balgarinova, Niya; Faculty of Medicine, Medical University of Varna, Stoimenova, Assena; Medical University - Sofia, Faculty of pharmacy, Department of Social Pharmacy, Bulgarian Drug Agency, Executive Director, Zaykova, Krassimira; Faculty of Medicine, Medical University of Varna   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Assessing computer skills in Tanzanian medical students: an elective experience [PDF]

, 2004
Background: One estimate suggests that by 2010 more than 30% of a physician's time will be spent using information technology tools. The aim of this study is to assess the information and communication technologies (ICT) skills of medical students in ...
Miriam Samuel, Samuel Miriam, Azarmina Pejman, Samuel, M., Miranda J Jaime, Young, E.J.W., Melvin, Rob, John C Coombes, Coombes John C, Pejman Azarmina, Melvin, R., Melvin Rob, Coombes, John C, Young, Eoin JW, Rob Melvin, Miranda, J Jaime, Coombes, J.C., Miranda, J.J., J Jaime Miranda, Azarmina, Pejman, Samuel, Miriam, Eoin JW Young, Young Eoin JW, Azarmina, P.   +23 more
core   +1 more source