Results 131 to 140 of about 2,307,247 (311)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Editorial: Innovative medical technology based on artificial cells, including its different configurations. [PDF]

Front Med Technol, 2023
Chang TMS.
europepmc   +1 more source

Incorporating Technology Adoption in Medical Education: A Qualitative Study of Medical Students’ Perspectives

Fahad Abdulaziz Alrashed,1 Tauseef Ahmad,1 Muneera M Almurdi,2 Asma A Alderaa,2 Saad A Alhammad,2 Mohammad Serajuddin,3 Abdulrahman M Alsubiheen2 1Department of Medical Education, College of Medicine, King Saud University, Riyadh, Saudi Arabia ...
Alderaa AA, Alsubiheen AM, Alrashed FA, Ahmad T, Almurdi MM, Serajuddin M, Alhammad SA   +6 more
core  

The place of the virtual dissection table Sectra in anatomy lessons of medical students

, 2017
Anatomy is a key discipline not only in the field of medical education, but also in the professional development of a young medical doctor. It is the first discipline for every healthcare student when starting his/her training.
Dotsova, R.; Medical University of Pleven, Rashev, T.; Medical University of Pleven, Ivanov, E.; Medical University of Pleven, Doseva, S.; Medical University of Pleven, Gerasimov, I.; Medical University of Pleven, Yochkova, S.; Medical University of Pleven, Todorov, A.; Medical University of Pleven, Trifonov, S.; Medical University of Pleven, Marinova, D.; Medical University of Pleven   +8 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Class of 1972-1973, school of medical technology, College of Allied Health Sciences

, 1973
Composite photograph of medical technology students in the Medical University of South Carolina, College of Health Professions, class of 1972-1973. Students pictured from left to right. Row 1: Bogart, P.G., Carlisle, C.F., Caver, S.F., Coles, J.A., Dover,
Medical University of South Carolina
core  

Dental Technology Protocol For Manufacturing 3d Printed Temporary Single Dental Crowns From The Next Dent CB Material

, 2019
Цел на обучението по една от основните задължителни дисциплини на студентите от специалност ,,Зъботехник` в Медицински колеж „Технология на зъбните протези` е да усвоят класическите и да се запознаят със съвременните технологии в зъбопротезирането.
Kuuse, Heli; Dental Technician Curriculum, Medical Education Centre, Tallinn Health Care College, Estonia, Simov, Maksim; TRS Dental Technician, Medical College, Medical University of Varna, Lakov, Alexandar; Student, TRS Dental Technician, Medical College, Medical University of Varna, Milev, Minko; TRS Dental Technician, Medical College, Medical University of Varna, Angelova, Svetlana; TRS Dental Technician, Medical College, Medical University of Varna, Dimitrova, Katerina; Student, TRS Dental Technician, Medical College, Medical University of Varna   +5 more
core   +1 more source