Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Realizing the value of complex medical technology: Demonstrating cost-effectiveness is not enough. [PDF]
Clin Transl Radiat Oncol, 2023 Hehakaya C +4 more
europepmc +1 more source
Characteristics of the Current Student Generation and Considerations for Medical Education
, 2012 Current medical students are a distinct new generation who can be distinguished from the previous generation. Therefore, a clear understanding of their characteristics is vital in developing an appropriate educational program for them.
연세대학교 의과대학
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Retracted: Intelligent Internet of Things Medical Technology in Implantable Intravenous Infusion Port in Children with Malignant Tumors. [PDF]
J Healthc Eng, 2023 Healthcare Engineering JO.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
MC-Injection Molding with Liquid Silicone Rubber (LSR) and Acrylonitrile Butadiene Styrene (ABS) for Medical Technology. [PDF]
Polymers (Basel), 2023 Nikousaleh MA +3 more
europepmc +1 more source
Improvements in medical care and technology and reductions in traffic-related fatalities in Great Britain [PDF]
Traffic-related fatalities in the UK have fallen dramatically over the last 30 years by about 50%. This decline has been observed in many other developed countries with similar rates of reduction.
Quddus, Mohammed Abdul, Noland, Robert
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of early diagnosis methods for asymmetric dementia in brain MR images based on genetic medical technology. [PDF]
Open Life Sci, 2023 Zhang X +6 more
europepmc +1 more source