Results 61 to 70 of about 4,243,211 (352)

Laymen and Medical Technology [PDF]

Annual Review of Public Health, 1981
The report of the US Surgeon-General for 1980 begins with the auspicious statement that the American people have never been healthier (1). As prime evidence, the report cites the fact that life expectancy for both sexes is now in the mid-seventies. Four diseases that at the tum of the century were major killers-diphtheria, tuberculosis, gastroenteritis,
openaire   +2 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Izazovi produljenja ljudskoga života na razmeđu poboljšanja i agonije

Diacovensia, 2020
The main aim of this paper is to present two different forms of human life extension. On the one hand there is dysthanasia, i.e. therapeutic persistence in the provision of life-sustaining measures to terminally ill patients, and on the other hand ...
Odilon-Gbènoukpo Singbo, Terezija Gložinić, Anto Čartolovni   +2 more
doaj   +1 more source

Implementing Patient-Centered Medical Home Pilot Projects: Lessons From AF4Q Communities [PDF]

, 2010
Shares lessons from Aligning Forces for Quality communities on creating medical homes to improve access to care, communication, and care coordination.

core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Overcoming Pilotitis in Digital Medicine at the Intersection of Data, Clinical Evidence, and Adoption

Advanced Intelligent Systems, 2022
Worldwide, digital medicine technologies are being developed at a rapid rate. While these digital medicine technologies offer the potential to transform and revolutionize health care, many are at risk of stalling and remaining in the pilot stage, known ...
Mathias Egermark, Agata Blasiak, Alexandria Remus, Yoann Sapanel, Dean Ho   +4 more
doaj   +1 more source

Enhancing the Capacity of Community Health Centers to Achieve High Performance [PDF]

, 2010
Based on a survey of community health centers, assesses access to care, care coordination, quality improvement efforts, health information technology adoption, and ability to serve as patient-centered medical homes.
Anne C. Beal, Kristof Stremikis, Melinda K. Abrams, Michelle M. Doty, Susan E. Hernandez   +4 more
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source