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Bacterial diversity in medication-related osteonecrosis of the jaw
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 The aim was to study the association between microflora and medication-related osteonecrosis of the jaw (MRONJ) by using culture-independent molecular techniques to detect bacteria in necrotic bone lesions.Included were 18 consecutive patients with MRONJ, 10 with osteoporosis and 8 cancer patients.
Fredrik, Hallmer +5 more
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Diagnosis and Staging of Medication-Related Osteonecrosis of the Jaw
Oral and Maxillofacial Surgery Clinics of North America, 2015 The relationship between osteonecrosis of the jaw and bisphosphonate therapy was initially established more than 10 years ago. Since that time our understanding of this disease process has evolved as the direct result of clinical, basic science, and ...
Salvatore L Ruggiero
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Medication-Related Osteonecrosis of the Jaw [PDF]
Oral and Maxillofacial Surgery Clinics of North America, 2015 In 2014, the nomenclature of bisphosphonate-related osteonecrosis of the jaw (BRONJ) was changed in medication-related osteonecrosis of the jaw (MRONJ) to include osteonecrosis of the jaw caused by non-bisphosphonates (BPs) drugs.
Pompa, Giorgio +5 more
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Management of Medication-Related Osteonecrosis of the Jaw
Oral and Maxillofacial Surgery Clinics of North America, 2015Medication-related osteonecrosis of the jaw (MRONJ) primarily involves patients receiving intravenous bisphosphonates for treatment of skeletal-related malignancies, oral bisphosphonates, and denosumab. There is no consensus regarding the clinical management of MRONJ.
William Bradford, Williams +1 more
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Medication-related osteonecrosis of the jaw
InnovAiT: Education and inspiration for general practice, 2020Medication-related osteonecrosis of the jaw (MRONJ) is a rare, but well-documented, complication following the administration of anti-resorptive and anti-angiogenic drugs. MRONJ has a negative effect on quality of life, and can result in reduced social contact, pain and masticatory difficulties. Prescription of implicated medication is within the remit
Kishan Patel +2 more
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Preventing medication-related osteonecrosis of the jaw
BMJ, 2019### What you need to know Osteonecrosis of the jaw is a severe adverse effect reported with certain drugs commonly used in the treatment of cancers and osteoporosis. Although rare, it can severely impair quality of life.1 The number and type of drugs associated with osteonecrosis of the jaw continue to increase, as do their indications.
Lara, Zebic, Vinod, Patel
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Interventions for managing medication-related osteonecrosis of the jaw
Cochrane Database of Systematic Reviews, 2022Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some individuals to certain medicines commonly used in the treatment of cancer and osteoporosis (e.g. bisphosphonates, denosumab, and antiangiogenic agents), and involves the progressive destruction of bone in the mandible or maxilla.
Natalie H, Beth-Tasdogan +4 more
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Medication-Related Osteonecrosis of the Jaws
2021Medication-related osteonecrosis of the jaw is an area of exposed bone in the maxilla or mandible that does not heal over a period of 6–8 weeks. It is a well-known side effect of bisphosphonate therapy, first described by Marx in 2003. More recently, other drugs have been incriminated: monoclonal antibodies inhibiting osteoclastic activity, such as ...
Leonor Costa Mendes, Bruno Courtois
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Medication-Related Osteonecrosis of the Jaw
New England Journal of Medicine, 2023Yu-Feng Chen, Hong-Po Chang
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Medication-related osteonecrosis of the jaw: the radiologist’s role
Radiología (English Edition), 2023In recent decades, the dreaded adverse effect of bisphosphonates, osteonecrosis of the jaw, has been widely reported and described in detail. Osteonecrosis of the jaw consists of the destruction of part of the maxilla as a consequence of these antiresorptive drugs.
R, Alemán Millares +3 more
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