Results 31 to 40 of about 1,923,096 (295)

RDS-04-010: a novel atypical DAT inhibitor that inhibits cocaine taking and seeking and itself has low abuse potential in experimental animals

Translational Psychiatry
Cocaine use disorder (CUD) is a severe public health problem, and currently, there is no FDA-approved medication for its treatment. Atypical dopamine (DA) transporter (DAT) inhibitors display low addictive liability by themselves and may have therapeutic
Omar Soler-Cedeno, Ewa Galaj, Benjamin Klein, Jianjing Cao, Guo-Hua Bi, Amy Hauck Newman, Zheng-Xiong Xi   +6 more
doaj   +1 more source

NEW DIRECTIONS IN ATHEROSCLEROSIS PHARMACOTHERAPY

Кардиоваскулярная терапия и профилактика, 2017
In the review, recent data presented, on possible targets for medications of specific pathogenetic action in atherosclerosis. The results described, of application of some drugs in complex treatment of atherosclerotic vessels lesions.
S. V. Dutova, Yu. V. Saranchina, O. Yu. Kilina, N. G. Polshcha, T. S. Kulakova, N. V. Khanarin   +5 more
doaj   +1 more source

The HIT Network for Children and Adolescents With CNS Tumors Facilitates Improvements of Diagnostic Assessments, Multimodal Treatments, Individual Counseling, and Research in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski, Michael C. Frühwald, Gudrun Fleischhack, Stephan Tippelt, Pablo Hernáiz‐Driever, Olaf Witt, Astrid Gnekow, Christof Kramm, Matthias Eyrich, Johannes E. A. Wolf, Hermann Müller, Carsten Friedrich, Uwe R. Kordes, Denise Obrecht‐Sturm, Petra Ketteler, Barbara von Zezschwitz, Pascal Johann, Dominik Sturm, Karoline Nemes, Stefan Schönberger, Till Milde, Brigitte Bison, Monika Warmuth‐Metz, Torsten Pietsch, Ulrich Schüller, Arend Koch, David Capper, Martin Hasselblatt, Christian Thomas, Christian Hagel, Stefan M. Pfister, Felix Sahm, David T. W. Jones, Martin U. Schuhmann, Jürgen Krauss, Pedram Emami, Ahmed El Damaty, Rolf D. Kortmann, Rudolf Schwarz, Jürgen Debus, Mechthild Krause, Fabian Pohl, Holger Ottensmeier, Lisa Bußenius, Katja Baust, Andreas Faldum, Cecile Ronckers, Desiree Grabow, Martin Benesch, Thomas Perwein, Karin Dieckmann, Irene Slavc, Johannes Gojo, Nicolas U. Gerber, André O. von Bueren, Katrin Scheinemann, Gabriele Calaminus, Beate Timmermann, Ulrich‐Wilhelm Thomale, Martin Mynarek   +59 more
wiley   +1 more source

CONTEMPORARY STRATEGY OF PULMONARY HYPERTENSION MANAGEMENT IN PEDIATRICS

Кардиоваскулярная терапия и профилактика, 2018
Pulmonary hypertension (PH) in pediatrics is a polygenic multifactorial condition with extremely adverse prognosis. Selection of optimal management is a severe task. In absence of treatment the mean life duration in children is not higher one year.
I. M. Miklashevich, М. A. Shkolnikova, S. V. Gorbachevsky, A. A. Shmalts, О. S. Groznova, D. I. Sadykova, L. V. Yakovleva, D. N. Degtyarev, A. A. Burov, D. Yu. Ovsyannikov, A. V. Volkov   +10 more
doaj   +1 more source

Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge

Cells, 2022
Cannabinoid receptor 1 (CB1R) has been one of the major targets in medication development for treating substance use disorders (SUDs). Early studies indicated that rimonabant, a selective CB1R antagonist with an inverse agonist profile, was highly ...
Omar Soler-Cedeno, Zheng-Xiong Xi
doaj   +1 more source

Medical nemesis [PDF]

Journal of Epidemiology and Community Health, 1974
This article was originally published in the Lancet in 1974.† It is reprinted here, as the centre of a set of articles, in memory of the death of Ivan Illich in December 2002.
openaire   +2 more sources

Stressful Events Reported by Childhood Cancer Survivors and Community Controls From the St. Jude Lifetime (SJLIFE) Cohort: A Mixed Method Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Characterizing stressful events reported by childhood cancer survivors experienced throughout the lifespan may help improve trauma‐informed care relevant to the survivor experience. Methods Participants included 2552 survivors (54% female; 34 years of age) and 469 community controls (62% female; 33 years of age) from the St.
Megan E. Ware, Colter K. Clayton, Fang Wang, Sedigheh Mirzaei, Kyla Shelton, Tara M. Brinkman, Victoria Willard, Katianne M. Howard Sharp, Kevin Krull, Lindsay F. Schwartz, Melissa M. Hudson, Gregory T. Armstrong, Kirsten K. Ness, Rachel T. Webster   +13 more
wiley   +1 more source

GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice

Translational Psychiatry
G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in cannabinoid action and substance use disorders.
Yi He, Hui Shen, Guo-Hua Bi, Hai-Ying Zhang, Omar Soler-Cedeño, Hannah Alton, Yihong Yang, Zheng-Xiong Xi   +7 more
doaj   +1 more source

The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors

Biomolecules
Modafinil analogs with either a sulfoxide or sulfide moiety have improved binding affinities at the human dopamine transporter (hDAT) compared to modafinil, with lead sulfoxide-substituted analogs showing characteristics of atypical inhibition (e.g ...
Kuo-Hao Lee, Gisela Andrea Camacho-Hernandez, Amy Hauck Newman, Lei Shi   +3 more
doaj   +1 more source

Influence of medications on taste and smell

World journal of otorhinolaryngology - head and neck surgery, 2018
Medications frequently have chemosensory side effects that can adversely affect compliance with medical treatment regimens. Hundreds of drugs have been reported to induce unpleasant tastes and/or odors as well as altered chemosensations when administered
S. Schiffman
semanticscholar   +1 more source