Results 11 to 20 of about 19,137 (183)
A transcriptomic approach to characterize human monocyte‐derived microglia‐like cells as a potential tool for identifying biological markers of mild cognitive impairment [PDF]
Alzheimers DementAbstract Background Microglial cells are critical in Alzheimer’s disease (AD) pathophysiology. Most human studies have analyzed microglia from postmortem brain samples or microglia derived from induced‐pluripotent stem cells. Our study provides evidence to support human monocyte‐derived microglia‐like cells as a cellular model to identify potential ...
Valdés‐Tovar M +11 more
europepmc +2 more sources
Educación Química, 2018 Durante los últimos veinte años el mundo ha sido testigo de cómo los científicos descifraron la secuencia del genoma humano y desarrollaron estrategias para estudiar extensivamente la diversidad genética, el desequilibrio del ligamiento (LD por sus ...
Irma Silva Zolezzi
doaj +1 more source
Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study
BMC Public Health, 2020 Background An Amerindian genetic background could play an important role in susceptibility to metabolic diseases, which have alarmingly increased in recent decades. Mexico has one of the highest prevalences of metabolic disease worldwide.
Elvia Cristina Mendoza-Caamal +17 more
doaj +1 more source
Nutrition & Diabetes, 2022 Background Obesity is accompanied by excess adipose fat storage, which may lead to adipose dysfunction, insulin resistance, and type 2 diabetes (T2D).
Paulina Baca +12 more
doaj +1 more source
Genomes, Diseases and Precision Medicine: a National Project [PDF]
, 2019 La medicina de precisión se presenta en los países centrales como un nuevo paradigma en el tratamiento de algunas enfermedades. Basada en el conocimiento del genoma de cada individuo, se sustenta en el principio de que el éxito en el tratamiento de las ...
Berenstein, Mariana Gisela +3 more
core +4 more sources
Cancer Cell International, 2020 Background Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the expression of several genes including fusion ones that results from structural ...
Carlos D. Cruz-Hernández +13 more
doaj +1 more source
Ethical and social issues of personalized medicine [PDF]
, 2017 A medicina personalizada tem como objetivo integrar a informação genética do indivíduo, os fatores ambientais a que este está exposto e o seu estilo de vida para identificar a sua predisposição à doença e as medidas preventivas, de promoção da saúde e
Alexander Brunker +3 more
core +2 more sources
Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study [PDF]
, 2015 Table S1. Demographic characteristics of the population. Table S2. Comparison of biochemical parameters stratified by gender and menopausal status. Table 3.
Aida Medina-Urrutia +10 more
core +2 more sources
Human Genomics, 2019 Interpretation of variants of unknown significance (VUS) in genetic tests is complicated in ethnically diverse populations, given the lack of information regarding the common spectrum of genetic variation in clinically relevant genes. Public availability
J. C. Fernández-Lopez +14 more
doaj +1 more source
Septic shock in ICU: Advanced therapeutics, immunoparalysis and genomics. State of the art [PDF]
, 2014 Indexación: Web of Science; Scielo.En las últimas décadas, se han incorporado nuevos y trascendentes conceptos para el tratamiento avanzado del paciente en shock séptico.
Arriagada S., Daniela +3 more
core +1 more source