Results 21 to 30 of about 19,518 (222)
Human Genomics, 2019 Interpretation of variants of unknown significance (VUS) in genetic tests is complicated in ethnically diverse populations, given the lack of information regarding the common spectrum of genetic variation in clinically relevant genes. Public availability
J. C. Fernández-Lopez +14 more
doaj +1 more source
A transcriptomic approach to characterize human monocyte‐derived microglia‐like cells as a potential tool for identifying biological markers of mild cognitive impairment [PDF]
Alzheimers DementAbstract Background Microglial cells are critical in Alzheimer’s disease (AD) pathophysiology. Most human studies have analyzed microglia from postmortem brain samples or microglia derived from induced‐pluripotent stem cells. Our study provides evidence to support human monocyte‐derived microglia‐like cells as a cellular model to identify potential ...
Valdés‐Tovar M +11 more
europepmc +2 more sources
Septic shock in ICU: Advanced therapeutics, immunoparalysis and genomics. State of the art [PDF]
, 2014 Indexación: Web of Science; Scielo.En las últimas décadas, se han incorporado nuevos y trascendentes conceptos para el tratamiento avanzado del paciente en shock séptico.
Arriagada S., Daniela +3 more
core +1 more source
Lifetime Bipolar Disorder comorbidity and related clinical characteristics in patients with primary Obsessive Compulsive Disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) [PDF]
, 2019 IntroductionBipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course.
Benatti, Beatrice +20 more
core +4 more sources
Antioxidants, 2023 Oxidative stress is essential in developing multiple bone metabolism diseases, including osteoporosis. Single-nucleotide variants (SNVs) have been associated with oxidative stress, promoting an imbalance between the production of reactive oxygen species ...
Rogelio F. Jiménez-Ortega +10 more
doaj +1 more source
Revista CEA, 2020 En este artículo se presenta el caso del Instituto Nacional de Medicina Genómica (INMEGEN) de la Secretaría de Salud del Gobierno Federal Mexicano, en el cual se realiza Investigación y Desarrollo (I&D) en Medicina Genómica.
Luis Roberto Vega-González +1 more
doaj +1 more source
Nature Communications, 2017 People of Mexico have diverse historical and genetic background. Here, Romero-Hidalgo and colleagues sequence whole genomes of Native Americans of Mexico, and show demographic history and genetic variation shared among subgroups of Native Americans.
Sandra Romero-Hidalgo +30 more
doaj +1 more source
Genomes, Diseases and Precision Medicine: a National Project [PDF]
, 2019 La medicina de precisión se presenta en los países centrales como un nuevo paradigma en el tratamiento de algunas enfermedades. Basada en el conocimiento del genoma de cada individuo, se sustenta en el principio de que el éxito en el tratamiento de las ...
Berenstein, Mariana Gisela +3 more
core +4 more sources
Molecular Genetics & Genomic Medicine, 2020 Background Dilated cardiomyopathy (DCM) is a major cause of nonischemic heart failure and death in young adults. Next generation sequencing (NGS) has become part of the diagnostic workup in idiopathic and familial DCM.
Alessandra Carnevale +11 more
doaj +1 more source
New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil
Frontiers in Oncology, 2021 The use of already-approved drugs to treat new or alternative diseases has proved to be beneficial in medicine, because it reduces both drug development costs and timelines.
Marian Cruz-Burgos +8 more
doaj +1 more source