Results 11 to 20 of about 4,845 (133)

SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo

Cancer Cell International, 2020
Background Prostate cancer (PCa) is the second cause of cancer related death in North American men. Androgens play an important role in its progression by regulating the expression of several genes including fusion ones that results from structural ...
Carlos D. Cruz-Hernández, Marian Cruz-Burgos, Sergio A. Cortés-Ramírez, Alberto Losada-García, Ignacio Camacho-Arroyo, Patricia García-López, Elizabeth Langley, Vanessa González-Covarrubias, Monserrat Llaguno-Munive, Martha E. Albino-Sánchez, José L. Cruz-Colín, Carlos Pérez-Plasencia, Fredy O. Beltrán-Anaya, Mauricio Rodríguez-Dorantes   +13 more
doaj   +1 more source

DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity

Nutrition & Diabetes, 2022
Background Obesity is accompanied by excess adipose fat storage, which may lead to adipose dysfunction, insulin resistance, and type 2 diabetes (T2D).
Paulina Baca, Francisco Barajas-Olmos, Elaheh Mirzaeicheshmeh, Carlos Zerrweck, Lizbeth Guilbert, Ernesto Carlos Sánchez, Marlen Flores-Huacuja, Rafael Villafán, Angélica Martínez-Hernández, Humberto García-Ortiz, Cecilia Contreras-Cubas, Federico Centeno-Cruz, Lorena Orozco   +12 more
doaj   +1 more source

Population and breast cancer patients’ analysis reveals the diversity of genomic variation of the BRCA genes in the Mexican population

Human Genomics, 2019
Interpretation of variants of unknown significance (VUS) in genetic tests is complicated in ethnically diverse populations, given the lack of information regarding the common spectrum of genetic variation in clinically relevant genes. Public availability
J. C. Fernández-Lopez, S. Romero-Córdoba, R. Rebollar-Vega, L. A. Alfaro-Ruiz, S. Jiménez-Morales, F. Beltrán-Anaya, R. Arellano-Llamas, A. Cedro-Tanda, M. Rios-Romero, M. Ramirez-Florencio, V. Bautista-Piña, C. Dominguez-Reyes, F. Villegas-Carlos, A. Tenorio-Torres, A. Hidalgo-Miranda   +14 more
doaj   +1 more source

Association Study between Antioxidant Nutrient Intake and Low Bone Mineral Density with Oxidative Stress-Single Nucleotide Variants: GPX1 (rs1050450 and rs17650792), SOD2 (rs4880) and CAT (rs769217) in Mexican Women

Antioxidants, 2023
Oxidative stress is essential in developing multiple bone metabolism diseases, including osteoporosis. Single-nucleotide variants (SNVs) have been associated with oxidative stress, promoting an imbalance between the production of reactive oxygen species ...
Rogelio F. Jiménez-Ortega, Diana I. Aparicio-Bautista, Adriana Becerra-Cervera, Priscilla López-Montoya, Guadalupe León-Reyes, Jeny Flores-Morales, Manuel Castillejos-López, Alberto Hidalgo-Bravo, Jorge Salmerón, Berenice Rivera-Paredez, Rafael Velázquez-Cruz   +10 more
doaj   +1 more source

Plan para desarrollar redes de vinculación y gestión en Instituciones de I&D en Salud: estudio de caso

Revista CEA, 2020
En este artículo se presenta el caso del Instituto Nacional de Medicina Genómica (INMEGEN) de la Secretaría de Salud del Gobierno Federal Mexicano, en el cual se realiza Investigación y Desarrollo (I&D) en Medicina Genómica.
Luis Roberto Vega-González, Roberto Misael Vega-Salinas   +1 more
doaj   +1 more source

Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing

Nature Communications, 2017
People of Mexico have diverse historical and genetic background. Here, Romero-Hidalgo and colleagues sequence whole genomes of Native Americans of Mexico, and show demographic history and genetic variation shared among subgroups of Native Americans.
Sandra Romero-Hidalgo, Adrián Ochoa-Leyva, Alejandro Garcíarrubio, Victor Acuña-Alonzo, Erika Antúnez-Argüelles, Martha Balcazar-Quintero, Rodrigo Barquera-Lozano, Alessandra Carnevale, Fernanda Cornejo-Granados, Juan Carlos Fernández-López, Rodrigo García-Herrera, Humberto García-Ortíz, Ángeles Granados-Silvestre, Julio Granados, Fernando Guerrero-Romero, Enrique Hernández-Lemus, Paola León-Mimila, Gastón Macín-Pérez, Angélica Martínez-Hernández, Marta Menjivar, Enrique Morett, Lorena Orozco, Guadalupe Ortíz-López, Fernando Pérez-Villatoro, Javier Rivera-Morales, Fernando Riveros-McKay, Marisela Villalobos-Comparán, Hugo Villamil-Ramírez, Teresa Villarreal-Molina, Samuel Canizales-Quinteros, Xavier Soberón   +30 more
doaj   +1 more source

Genomic study of dilated cardiomyopathy in a group of Mexican patients using site‐directed next generation sequencing

Molecular Genetics & Genomic Medicine, 2020
Background Dilated cardiomyopathy (DCM) is a major cause of nonischemic heart failure and death in young adults. Next generation sequencing (NGS) has become part of the diagnostic workup in idiopathic and familial DCM.
Alessandra Carnevale, Sandra Rosas‐Madrigal, Rigoberto Rosendo‐Gutiérrez, Enrique López‐Mora, Sandra Romero‐Hidalgo, Nydia Avila‐Vazzini, Leonor Jacobo‐Albavera, Mayra Domínguez‐Pérez, Gilberto Vargas‐Alarcón, Fernando Pérez‐Villatoro, Juana Inés Navarrete‐Martínez, María Teresa Villarreal–Molina   +11 more
doaj   +1 more source

New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil

Frontiers in Oncology, 2021
The use of already-approved drugs to treat new or alternative diseases has proved to be beneficial in medicine, because it reduces both drug development costs and timelines.
Marian Cruz-Burgos, Alberto Losada-Garcia, Carlos D. Cruz-Hernández, Sergio A. Cortés-Ramírez, Ignacio Camacho-Arroyo, Vanessa Gonzalez-Covarrubias, Miguel Morales-Pacheco, Samantha I. Trujillo-Bornios, Mauricio Rodríguez-Dorantes   +8 more
doaj   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome

Computational and Structural Biotechnology Journal, 2015
The advances in experimental methods and the development of high performance bioinformatic tools have substantially improved our understanding of microbial communities associated with human niches.
Shirley Bikel, Alejandra Valdez-Lara, Fernanda Cornejo-Granados, Karina Rico, Samuel Canizales-Quinteros, Xavier Soberón, Luis Del Pozo-Yauner, Adrián Ochoa-Leyva   +7 more
doaj   +1 more source