Results 211 to 220 of about 1,538,508 (356)

ACS Medicinal Chemistry Letters [PDF]

, 2009

openalex   +1 more source

Medicinal chemistry breakthroughs on ATM, ATR, and DNA-PK inhibitors as prospective cancer therapeutics. [PDF]

J Enzyme Inhib Med Chem
Sharma R, Mishra A, Bhardwaj M, Singh G, Indira Harahap LV, Vanjani S, Pan CH, Nepali K.   +7 more
europepmc   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Chemistry in Medicine [PDF]

Soil Science, 1929
openaire   +4 more sources

Detection, analysis, and visualization of relevant scaffolds in medicinal chemistry project databases [PDF]

, 2009
A. M. Clark
openalex   +1 more source

Use of Aldehyde-Alkyne-Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers. [PDF]

ACS Med Chem Lett
McGown A, Vetma V, Crepin D, Lin Y, Adcock C, Craigon C, Nafie J, von Emloh D, Sutton L, Bailey K, Edmunds L, Sharma M, Wilden JD, Coles SJ, Tizzard GJ, Farnaby W, Ciulli A, Kostakis GE, Spencer J.   +18 more
europepmc   +1 more source

Medicinal Resources, Natural Products Chemistry [PDF]

, 2007
アワレ スレス, 手塚 康弘, 門田 重利   +2 more
core   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity. [PDF]

Molecules
Murtazaeva Z, Nasrullaev A, Buronov A, Gaybullaev S, Nie L, Numonov S, Khushnazarov Z, Turgunov D, Kuryazov R, Zhao J, Bozorov K.   +10 more
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source