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Chemistry, 2022
Extension of the medicinal chemistry toolbox is in the vital interest of drug designers. However, the diffusion of an innovation can be a lengthy process.
U. Lücking
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Extension of the medicinal chemistry toolbox is in the vital interest of drug designers. However, the diffusion of an innovation can be a lengthy process.
U. Lücking
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Benzoxazine: a privileged scaffold in medicinal chemistry.
Current Medicinal Chemistry, 2022BACKGROUND Benzoxazine is one of the most important privileged scaffolds in medicinal chemistry. Compounds bearing benzoxazine moiety usually have a variety of biological activities, such as anti-inflammatory, anti-microbial, anti-tuberculosis, anti ...
Zilong Tang +3 more
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The Medicinal Chemistry of Caffeine.
Journal of Medicinal Chemistry, 2021The purine alkaloid caffeine is the most widely consumed psychostimulant drug in the world and has multiple beneficial pharmacological activities, for example, in neurodegenerative diseases. However, despite being an extensively studied bioactive natural
Giuseppe Faudone, Silvia Arifi, D. Merk
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Drug Discovery Today, 2006
With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved
Marcus, Koppitz, Knut, Eis
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With the advent of high throughput technologies in biological screening in the 1980s, providing sufficient numbers of small molecules for screening became a bottleneck in the drug discovery process. Combinatorial chemistry was the first attempt by chemists to address this issue. However, since its first applications, combinatorial chemistry has evolved
Marcus, Koppitz, Knut, Eis
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Asymmetric organocatalysis: an enabling technology for medicinal chemistry.
Chemical Society Reviews, 2021The efficacy and synthetic versatility of asymmetric organocatalysis have contributed enormously to the field of organic synthesis since the early 2000s.
Bo Han +5 more
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What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries.
Journal of Medicinal Chemistry, 2021Building blocks are the molecular foundations for drug molecule design. The building block is one of the determining factors of final compound qualities in any given medicinal chemistry campaign.
Ying Wang +3 more
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