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Proteomics in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry, 2006Proteomics is becoming an important research area for studying protein expression patterns induced by different external stimuli. An important aspect of proteomics is to identify and quantify proteins. Many new technologies and techniques have been developed in this field and have been applied to various aspects of drug discovery.
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Macromolecular Chemistry and Medicine
Angewandte Chemie International Edition in English, 1970AbstractMacromolecular substances are used in medicine both as materials and as reagents. In the former category polymers serve as replacements for soft tissue, as cardiovascular and orthopedic implants, and as adhesives. When employed as reagents, macromolecules interact with living tissue and play an active part in bodily repair processes.
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The Medicinal Chemistry of Peptides
Current Medicinal Chemistry, 2009The shortcomings of native peptides as pharmaceuticals have been long known: short duration of action, lack of receptor selectivity, lack of oral bioavailability. However medicinal chemistry offers solutions to the first two limitations and oral bioavailability issues have been addressed with novel routes of administration (e.g. intranasal, inhalation)
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The impact of click chemistry in medicinal chemistry
Expert Opinion on Drug Discovery, 2012The copper(I)-catalyzed 1,3-dipolar cycloaddition of alkynes and azides to form 1,2,3-triazoles is the most popular reaction in click chemistry. This reaction is also near-perfect, in terms of its robustness, due to the high degree of reliability and complete specificity.
Jingli, Hou +4 more
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Current Medicinal Chemistry, 2014
Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemical experimental results.
M O, Almeida +5 more
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Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemical experimental results.
M O, Almeida +5 more
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Automation in Medicinal Chemistry
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Fluorine in Medicinal Chemistry
2015Since its first use in the steroid field in the late 1950s, the use of fluorine in medicinal chemistry has become commonplace, with the small electronegative fluorine atom being a key part of the medicinal chemist's repertoire of substitutions used to modulate all aspects of molecular properties including potency, physical chemistry and ...
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2003
In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
H, Kessler +5 more
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In the past decade, nuclear magnetic resonance (NMR) spectroscopy has gained an enormous impact on drug research, due to its extraordinary capacity to measure properties and observe changes at individual atomic positions even in very complex systems. While the analysis of molecular structures still is the main goal of classical NMR investigations, it ...
H, Kessler +5 more
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Perspectives in Medicinal Chemistry: The Evolution of Medicinal Chemistry
Current Topics in Medicinal Chemistry, 2015J Phillip, Bowen, Haizhen A, Zhong
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