Results 251 to 260 of about 4,033,374 (391)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Personalizing Self-Management Interventions in COPD – Looking Beyond One-Size-Fits-All

International Journal of COPD
Anke Lenferink,1,2 Marjolein GJ Brusse-Keizer,1,3 Job van der Palen,3,4 Tanja W Effing5,6 1Health Technology and Services Research, Faculty of Behavioural, Management and Social Sciences, Technical Medical Centre, University of Twente, Enschede, The ...
Lenferink A, Brusse-Keizer MG, van der Palen J, Effing TW   +3 more
doaj  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The missing trans women of science, medicine, and global health [PDF]

The Lancet, 2019
Arjee J, Restar, Don, Operario
openaire   +2 more sources

Enhancing physiology teaching and learning through the use of holograms in health sciences and medicine [PDF]

, 2020
Christian Moro, Charlotte Phelps, Zane Štromberga   +2 more
openalex  

Subclinical Hypothyroidism and Pregnancy: The Intersection of Science, the Art of Medicine, and Public Health Policy [PDF]

, 2014
Alex Stagnaro‐Green
openalex   +1 more source