Results 111 to 120 of about 4,187,936 (295)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature. [PDF]

open access: yesFront Pharmacol, 2022
Zhang CS   +7 more
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Novi prilog poznavanju povijesti liburnijskoga planinarstva: djelovanje Hrvatskoga planinarskog društva "Tris" Lovran (2002. - 2019.)

open access: yesZbornik Lovranšćine
Hrvatsko planinarsko društvo „TRIS” (dalje: Društvo) u lokalnoj i regionalnoj planinarskoj i kulturnoj povijesti ostalo je gotovo u potpunosti nezamijećeno, a njegov rad potpuno nerasvijetljen.
Igor Eterović, Ivana Eterović
doaj   +1 more source

Precision Medicine in Periodontics: A Literature Review

open access: yesCureus
Periodontitis, a widespread health issue, requires effective prevention and management strategies due to its increasing prevalence and detrimental social consequences. The chronic inflammation associated with periodontitis also exacerbates systemic conditions, emphasizing the need for advanced approaches in addressing this public health concern.
Gundelly, Mrunalini   +5 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Artificial Intelligence in Emergency Medicine: A Literature Review

open access: yesQuality in Sport
Introduction Artificial intelligence (AI) is rapidly transforming medical fields, particularly emergency medicine (EM), where timely decision-making is crucial.
Gracjan Sitarek, Marta Żerek
doaj   +1 more source

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