Results 171 to 180 of about 14,042 (211)

Evaluation of common mutations in the Mediterranean fever gene in Multiple Sclerosis patients: Is it a susceptibility gene?

Journal of the Neurological Sciences, 2010
Multiple Sclerosis (MS) is a disease of the central nervous system characterized by multiple areas of inflammation and demyelination in the white matter of the brain and spinal cord. MEFV gene, which is the main factor in familial Mediterranean fever, is an intracellular regulator of inflammation. This study was designed to determine if known mutations
Aysun Ünal, Ahmet Dursun, Ufuk Emre
exaly   +4 more sources

Mediterranean fever gene variants and colchicine therapy in periodic fever, aphthous stomatitis pharyngitis, adenitis syndrome in a Mediterranean region.

Expert review of clinical immunology, 2019
PubMedID ...
Haytoglu Z., Gundeslioglu O.O.
openaire   +3 more sources

Familial Mediterranean Fever Gene

New England Journal of Medicine, 1998
To the Editor: Babior and Matzner (Nov. 20 issue)1 state that the recently identified familial Mediterranean fever (FMF) gene2,3 can be used to establish the diagnosis of this disease.
A H, Holmes, D R, Booth, P N, Hawkins
openaire   +2 more sources

A candidate gene for familial Mediterranean fever

Nature Genetics, 1997
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by attacks of fever and serositis. In this paper, we define a minimal co-segregating region of 60 kb containing the FMF gene (MEFV) and identify four different transcript units within this region.
null The French FMF Consortium, Alain Bernot, Christian Clepet, Corinne Dasilva, Catherine Devaud, Jean-Louis Petit, Christophe Caloustian, Corinne Cruaud, Delphine Samson, Françoise Pulcini, Jean Weissenbach, Roland Heilig, Cécile Notanicola, Cécile Domingo, Michael Rozenbaum, Eldad Benchetrit, Rezzan Topaloglu, Marie Dewalle, Christiane Dross, Philippe Hadjari, Madeleine Dupont, Jacques Demaille, Isabelle Touitou, Nizar Smaoui, Brigitte Nedelec, Jean-Philippe Méry, Habiba Chaabouni, Marc Delpech, Gilles Grateau   +28 more
openaire   +2 more sources

The clinical effect of gene mutations in familial Mediterranean fever disease

Pediatrics International, 2022
AbstractBackgroundFamilial Mediterranean fever (FMF) is a self‐limiting, autoinflammatory disease characterized by inflammation of the serosal surfaces and recurrent episodes of fever. The aim of this study is to determine the effect of genetic mutations on clinical features in children with FMF.MethodsA total of 303 patients aged 0–18 years, who were ...
Vildan Güngörer, Alaaddin Yorulmaz, Şükrü Arslan   +2 more
openaire   +2 more sources

Mediterranean fever gene-associated enterocolitis in an elderly Japanese woman

Clinical Journal of Gastroenterology, 2021
An 86-year-old woman was admitted to our hospital with anemia. She had never experienced symptoms of serositis. Colonoscopy revealed colitis with erosions and a friable mucosa. First, she was diagnosed with unclassified inflammatory bowel disease (IBD-U).
Yasuhiro, Shibata, Keisuke, Ishigami, Tomoe, Kazama, Toshiyuki, Kubo, Hiro-O, Yamano, Shintaro, Sugita, Masaki, Murata, Hiroshi, Nakase   +7 more
openaire   +2 more sources

The Familial Mediterranean Fever Gene — Cloned at Last

New England Journal of Medicine, 1997
Familial Mediterranean fever is an inherited condition prevalent among people of the Near East — Arabs, Turks, Armenians, and Sephardic Jews.1 Transmitted as an autosomal recessive trait, familial ...
B M, Babior, Y, Matzner
openaire   +2 more sources

Mapping of the Familial Mediterranean Fever Gene to Chromosome 16

American Journal of Reproductive Immunology, 1992
ABSTRACT: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent attacks of fever, synovitis, peritonitis, or pleurisy. Some patients eventually develop systemic amyloidosis. The biochemical cause of the disease is unknown. We have conducted a genome‐wide search for the FMF locus using 125 different DNA markers
L, Gruberg, I, Aksentijevich, E, Pras, D L, Kastner, M, Pras   +4 more
openaire   +2 more sources

Familial Mediterranean fever gene and protection against asthma

Annals of Allergy, Asthma & Immunology, 2007
Asthma is an inflammatory airway disease caused by interaction between susceptibility genes and diverse environmental factors. In Israel, asthma seems to be familial and more severe in patients of Iraqi Jewish descent. On the other hand, asthma is less frequent in individuals with familial Mediterranean fever, an autoinflammatory disease prevalent in ...
Einat, Rabinovitch, Dror, Harats, Pnina, Yaron, Tamar, Luvish, Merav, Lidar, Ron, Kedem, Aviv, Shaish, Issahar, Ben-Dov, Avi, Livneh   +8 more
openaire   +2 more sources

The Familial Mediterranean Fever (MEVF) Gene as a Modifier of Crohn's Disease

The American Journal of Gastroenterology, 2005
Crohn's disease (CD) has been reported to be more frequent among non-Ashkenazi Jewish patients suffering from familial Mediterranean fever (FMF). Interestingly, functional similarities between the CD susceptibility gene (NOD2/CARD15) and the FMF gene (MEFV) have been described: both belong to the death domain containing protein family, important in the
Herma, Fidder, Yehuda, Chowers, Zvi, Ackerman, Rivka Dresner, Pollak, J Bart A, Crusius, Avi, Livneh, Simon, Bar-Meir, Benjamin, Avidan, Yael, Shinhar   +8 more
openaire   +2 more sources